◀ Back to EGFR

EGFR — EPAS1

Text-mined interactions from Literome

Franovic et al., Proc Natl Acad Sci U S A 2007 (Neoplasms) : Here, we provide evidence that overexpression of wild-type EGFR can be induced by the hypoxic microenvironment and activation of hypoxia-inducible factor 2-alpha ( HIF2alpha ) in the core of solid tumors ... Taken together, our findings provide a nonmutational explanation for EGFR overexpression in human tumors and highlight a role for HIF2alpha activation in the regulation of EGFR protein synthesis
Wang et al., Carcinogenesis 2010 (Carcinoma, Squamous Cell...) : HIF-2alpha mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia