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EPHA2 — MAPK8

Text-mined interactions from Literome

Gu et al., Oncogene 2005 (Brain Neoplasms...) : Consistent with these results, EphA8 expression induced a sustained increase in the activity of MAPK , whereas ligand mediated EphA8 activation had no further modulatory effects on MAP kinase activity
Brantley-Sieders et al., J Clin Invest 2008 (Adenocarcinoma...) : However, while EphA2 has been reported to enhance tumorigenesis, proliferation, and MAPK activation in several model systems, other studies suggest that EphA2 activation diminishes these processes and inhibits the activity of MAPK upon ligand stimulation
Zhang et al., Cancer Res 2008 (MAP Kinase Signaling System...) : However, inhibition of mitogen activated protein kinase ( MAPK ) signaling by U0126 and PD98059 significantly reduced the UVR response whereas overexpression of oncogenic NRAS led to an increase in EphA2
Day et al., Cancer Cell 2013 (Brain Neoplasms...) : Importantly, EphA3 is highly expressed on the tumor initiating cell population in glioma and appears critically involved in maintaining tumor cells in a less differentiated state by modulating mitogen activated protein kinase signaling
Liu et al., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2013 (Carcinoma, Squamous Cell...) : The expression of phosphorylated p38 MAPK was obviously increased in Tu686 cells with EphA2 overexpression