Gene interactions and pathways from curated databases and text-mining

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CASP4 — EPX

Text-mined interactions from Literome

Chong et al., J Cereb Blood Flow Metab 2003 : Consistent with the modulation of Apaf-1 and the release of cytochrome c, EPO also inhibits the activation of caspase-9 and caspase-3-like activities
Wu et al., Apoptosis 2007 : EPO induced sustained phosphorylation of Akt and its substrate, GSK-3beta, reduced caspase-3 activities in PC12 cells
Xie et al., Eye (Lond) 2012 (Disease Models, Animal...) : Intravitreal injection of EPO 400 ng is safe, and EPO may suppress caspase-3 activation and enhance Bcl-X ( L ) expression, resulting in inhibition of apoptosis and protection of photoreceptor cells