◀ Back to PIK3R1
ERBB4 — PIK3R1
Pathways - manually collected, often from reviews:
-
KEGG ErbB signaling pathway:
Complex of ERBB4
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG ErbB signaling pathway:
Complex of ERBB2-ERBB4
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
NCI Pathway Database ErbB4 signaling events:
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta complex (ERBB4-NRG1)
→
PI3K Class IA family (PIK3CA/PIK3R1/PIK3CB/PIK3R1)
(modification, activates)
Elenius et al., Oncogene 1999*, Sweeney et al., J Biol Chem 2000, Cohen et al., J Biol Chem 1996
Evidence: assay, physical interaction
-
NCI Pathway Database ErbB4 signaling events:
ErbB4/ErbB4/HBEGF/HBEGF complex (ERBB4-HBEGF)
→
PI3K Class IA family (PIK3CA/PIK3R1/PIK3CB/PIK3R1)
(modification, activates)
Elenius et al., EMBO J 1997
Evidence: assay, physical interaction
-
Reactome Reaction:
PIK3R1
→
ERBB4
(indirect_complex)
Kaushansky et al., Chem Biol 2008, Cohen et al., J Biol Chem 1996
-
Reactome Reaction:
PIK3R1
→
ERBB4
(reaction)
Kaushansky et al., Chem Biol 2008, Cohen et al., J Biol Chem 1996
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Tal-Or et al., J Cell Biochem 2006
:
The
PI3K inhibitor LY294002 and the MEK inhibitor PD98059
caused a partial inhibition of the Ras induced
ErbB4 receptor phosphorylation
Seshadri et al., Proc Natl Acad Sci U S A 2010
:
Receptors ErbB2 and ErbB3, but not
ErbB4 , are responsible for transducing this effect, and
PI3K/Akt signaling is also
required