Gene interactions and pathways from curated databases and text-mining

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ESR1 — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sun et al., Cancer Res 2001 (Breast Neoplasms) : Moreover, we found that ERalpha binds to the p85alpha regulatory subunit of PI3K in the absence or presence of estradiol in epithelial cells and subsequently activates PI3K/AKT2 , suggesting ERalpha regulation of PI3K/AKT2 through a nontranscriptional and ligand independent mechanism
Simoncini et al., Arterioscler Thromb Vasc Biol 2003 : By using cultured human saphenous vain endothelial cells, we found that cell membrane bound ERalpha colocalizes with PI3K and may be responsible for PI3K activation
Pozo-Guisado et al., Int J Cancer 2004 (Breast Neoplasms) : Stimulation of PI3K activity by RES was ERalpha dependent since it could be blocked by the antiestrogen ICI 182,780
Simoncini et al., Steroids 2004 : For instance, estrogens and glucocorticoids trigger rapid vasodilatation due to rapid induction of nitric oxide synthesis in endothelial cells via the estrogen receptor dependent activation of MAPK and PI3K , leading to relevant pathophysiological consequences, in vitro and in vivo
Tissier et al., J Mol Cell Cardiol 2007 (Myocardial Infarction...) : In conclusion, genistein exerts pharmacological postconditioning with a similar potency as 17beta-estradiol through a pathway involving activation of the estrogen receptor , of PI3K/Akt and mitochondrial preservation
Benitez et al., Br J Cancer 2007 (Breast Neoplasms...) : Immunoprecipitation and kinase assays showed that RES inhibited AR- and ERalpha dependent PI3K activities in LNCaP and PC-3, respectively
Ma et al., Mol Endocrinol 2007 : BRCA1 underexpression also enhanced estrogen-inducible ER-alpha activity in a PI3K/Akt dependent manner
Lee et al., Mol Cells 2008 (Breast Neoplasms) : In contrast, the effect of the PI3K/Akt inhibitor on ER alpha was blocked in cells that were treated with LY294002 in the presence of the proteasome inhibitors
Hwang et al., Toxicol Appl Pharmacol 2008 : Mechanism of phytoestrogen puerarin mediated cytoprotection following oxidative injury : estrogen receptor dependent up-regulation of PI3K/Akt and HO-1
Hwang et al., Toxicol Appl Pharmacol 2011 : These results indicate that puerarin stimulates eNOS phosphorylation and NO production via activation of an estrogen receptor mediated PI3K/Akt- and CaMKII/AMPK dependent pathway
Shi et al., Biochim Biophys Acta 2013 : Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor mediated PI3K/GSK3beta signaling