Gene interactions and pathways from curated databases and text-mining

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ESR2 — PIK3R1

Text-mined interactions from Literome

Simoncini et al., Steroids 2004 : For instance, estrogens and glucocorticoids trigger rapid vasodilatation due to rapid induction of nitric oxide synthesis in endothelial cells via the estrogen receptor dependent activation of MAPK and PI3K , leading to relevant pathophysiological consequences, in vitro and in vivo
Tissier et al., J Mol Cell Cardiol 2007 (Myocardial Infarction...) : In conclusion, genistein exerts pharmacological postconditioning with a similar potency as 17beta-estradiol through a pathway involving activation of the estrogen receptor , of PI3K/Akt and mitochondrial preservation
Gingerich et al., Neuropharmacology 2008 : Finally, we demonstrate that Src kinase acts upstream of the PI3K/Akt pathway based on our finding that the selective Src inhibitor, PP2 ( 10microM ), blocked the increases in nNOS phosphorylation levels, NO production, and PI3K/Akt activity induced by ERbeta activation
Hwang et al., Toxicol Appl Pharmacol 2008 : Mechanism of phytoestrogen puerarin mediated cytoprotection following oxidative injury : estrogen receptor dependent up-regulation of PI3K/Akt and HO-1
Hwang et al., Toxicol Appl Pharmacol 2011 : These results indicate that puerarin stimulates eNOS phosphorylation and NO production via activation of an estrogen receptor mediated PI3K/Akt- and CaMKII/AMPK dependent pathway
Shi et al., Biochim Biophys Acta 2013 : Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor mediated PI3K/GSK3beta signaling