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ESR2 — PIK3R1
Text-mined interactions from Literome
Simoncini et al., Steroids 2004
:
For instance, estrogens and glucocorticoids trigger rapid vasodilatation due to rapid induction of nitric oxide synthesis in endothelial cells via the
estrogen receptor dependent
activation of MAPK and
PI3K , leading to relevant pathophysiological consequences, in vitro and in vivo
Tissier et al., J Mol Cell Cardiol 2007
(Myocardial Infarction...) :
In conclusion, genistein exerts pharmacological postconditioning with a similar potency as 17beta-estradiol through a pathway involving
activation of the
estrogen receptor , of
PI3K/Akt and mitochondrial preservation
Gingerich et al., Neuropharmacology 2008
:
Finally, we demonstrate that Src kinase acts upstream of the PI3K/Akt pathway based on our finding that the selective Src inhibitor, PP2 ( 10microM ), blocked the increases in nNOS phosphorylation levels, NO production, and
PI3K/Akt activity
induced by
ERbeta activation
Hwang et al., Toxicol Appl Pharmacol 2008
:
Mechanism of phytoestrogen puerarin mediated cytoprotection following oxidative injury :
estrogen receptor dependent up-regulation of
PI3K/Akt and HO-1
Hwang et al., Toxicol Appl Pharmacol 2011
:
These results indicate that puerarin stimulates eNOS phosphorylation and NO production via activation of an
estrogen receptor mediated
PI3K/Akt- and CaMKII/AMPK dependent pathway
Shi et al., Biochim Biophys Acta 2013
:
Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via
estrogen receptor mediated
PI3K/GSK3beta signaling