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EVPL — HRAS
Text-mined interactions from Literome
Tauchi et al., J Exp Med 1994
:
In this context, experiments were performed to evaluate a protein signaling pathway by which
p210bcr-abl might
regulate p21ras
Mandanas et al., Blood 1993
(Cell Transformation, Neoplastic) :
Inhibition of
p210 bcr-abl dependent tyrosine phosphorylation
resulted in a reduction of active
p21RAS-GTP complexes in the transformed cells, in diminished expression of the nuclear early response genes c-jun and c-fos, and in lower cellular proliferation rate
Skorski et al., J Exp Med 1994
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
Therefore, we investigated whether
p21ras and p120GAP are
regulated by
p210bcr/abl , and whether this activation is functionally significant for CML cell proliferation ... We report that transient expression of p210bcr/abl in fibroblast-like cells induces simultaneous activation of p21ras and inhibition of GTPase promoting activity of p120GAP, and confirm these data showing that downregulation of
p210bcr/abl expression in CML cells with bcr/abl antisense oligodeoxynucleotides
induces both inhibition of
p21ras activation and stimulation of GTPase promoting activity of p120GAP