Gene interactions and pathways from curated databases and text-mining

◀ Back to HRAS

EVPL — HRAS

Text-mined interactions from Literome

Tauchi et al., J Exp Med 1994 : In this context, experiments were performed to evaluate a protein signaling pathway by which p210bcr-abl might regulate p21ras
Mandanas et al., Blood 1993 (Cell Transformation, Neoplastic) : Inhibition of p210 bcr-abl dependent tyrosine phosphorylation resulted in a reduction of active p21RAS-GTP complexes in the transformed cells, in diminished expression of the nuclear early response genes c-jun and c-fos, and in lower cellular proliferation rate
Skorski et al., J Exp Med 1994 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : Therefore, we investigated whether p21ras and p120GAP are regulated by p210bcr/abl , and whether this activation is functionally significant for CML cell proliferation ... We report that transient expression of p210bcr/abl in fibroblast-like cells induces simultaneous activation of p21ras and inhibition of GTPase promoting activity of p120GAP, and confirm these data showing that downregulation of p210bcr/abl expression in CML cells with bcr/abl antisense oligodeoxynucleotides induces both inhibition of p21ras activation and stimulation of GTPase promoting activity of p120GAP