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F2R — PLG
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Mitchell et al., Blood 2006
:
The cytoprotective effect of
plasminogen requires plasmin proteolytic activity and
requires PAR1
Nagai et al., J Neurosci 2006
:
Furthermore, we demonstrated that
plasmin activated
PAR1 and that nicotine induced place preference and dopamine release were diminished in PAR1-deficient (PAR1-/-) mice
Kamio et al., Biochem Pharmacol 2008
(Inflammation) :
These results suggest that
plasmin activates
PAR-1 and is involved in inflammation in human dental pulp
Nagai et al., Nihon Arukoru Yakubutsu Igakkai Zasshi 2008
(Tobacco Use Disorder) :
Furthermore, we demonstrated that
plasmin activated
PAR1 and that nicotine induced place preference and dopamine release were diminished in PAR1-deficient (PAR1-/-) mice
Nagai et al., J Pharmacol Sci 2008
(Tobacco Use Disorder) :
The expression of PAR(1) on dopaminergic neurons is evident and the
activation of
PAR(1) by
plasmin is demonstrated by assaying GTP-gammaS binding
Osuga et al., Front Biosci (Elite Ed) 2012
(Endometriosis) :
PAR1 activation in endometrial stromal cells induces production of vascular endothelial growth factor and matrix metalloproteinases, and
increases activities of tissue-type and urokinase-type
plasminogen activator
Osuga et al., Front Biosci (Schol Ed) 2012
(Endometriosis) :
PAR1 activation in endometrial stromal cells induces production of vascular endothelial growth factor and matrix metalloproteinases, and
increases activities of tissue-type and urokinase-type
plasminogen activator
Tudpor et al., J Am Soc Nephrol 2012
(Calcium Signaling...) :
In summary,
PAR-1 activation by
plasmin induces PKC mediated phosphorylation of TRPV5, thereby altering calmodulin-TRPV5 binding, resulting in decreased channel activity
Takada et al., J Biomed Biotechnol 2012
:
One possible mechanism of angiostatin 's inhibitory action is that angiostatin suppresses
plasmin induced
PAR-1 activation by competing with plasmin for binding to integrins