◀ Back to FGF4
FGF1 — FGF4
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
FGF1
→
FGF4
(reaction)
Carpenter et al., Exp Cell Res 1999, Hart et al., Mol Biol Cell 2001, Wong et al., Proc Natl Acad Sci U S A 2002, Lax et al., Mol Cell 2002, Fong et al., J Biol Chem 2003, Mohammadi et al., Nature 1992, Agazie et al., Oncogene 2003, Ibrahimi et al., Hum Mol Genet 2004, Furdui et al., Mol Cell 2006, Mohammadi et al., Mol Cell Biol 1991, Dionne et al., EMBO J 1990, Takeda et al., Clin Cancer Res 2007, Ahmed et al., Biochem J 2008, Byron et al., Cancer Res 2008, Schüller et al., Biochem J 2008, Qing et al., J Clin Invest 2009, Turner et al., Nat Rev Cancer 2010, Bai et al., Cancer Res 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Wang et al., Mol Cell Biol 1994, Mohammadi et al., Mol Cell Biol 1996, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Mohammadi et al., Science 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998, Raffioni et al., J Biol Chem 1998
Text-mined interactions from Literome
Crumley et al., Oncogene 1991
:
High-affinity binding and
activation of a truncated
FGF receptor by both
aFGF and bFGF
Yamamoto et al., J Biol Chem 2008
:
PDGF-AA induced the expression of the
fibroblast growth factor genes Fgf3 and -7, and PDGF-BB
induced the expression of
Fgf1 , -3, -7, and -10, whereas short interfering RNA for Pdgfa and Pdgfb inhibited the expression of Fgf3, -7, and -10, indicating that PDGFs regulate Fgf gene expression in SMG mesenchyme
Blagovic et al., PloS one 2011
:
Then we induce
FGF4 signaling in minimal chemically defined medium ( N2B27 ) and
inhibit FGF signaling in fully supplemented differentiation medium with cell secreted factors to determine that the non-FGF cell secreted factors are required to promote growth of differentiating mESCs
Mori et al., PloS one 2013
(Colonic Neoplasms...) :
R50E is defective in inducing ternary complex formation, cell proliferation, and cell migration, and suppresses
FGF signaling
induced by WT
FGF1 ( a dominant negative effect ) in vitro
Jouanneau et al., Growth Factors 1995
(Carcinoma...) :
Our results indicate that the expression of
FGF-1 may promote tumor growth, at least in part, by inducing angiogenesis, and that the acquired ability of tumor cells to secrete FGF-1 but not
FGF-4 , may
result in aberrant neovascularization of the tumor
Relf et al., Cancer Res 1997
(Breast Neoplasms...) :
Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic
fibroblast growth factor , tumor growth factor beta-1, platelet
derived endothelial cell growth factor , placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
Zuber et al., J Cell Physiol 1997
:
Cysteine-rich
FGF receptor
regulates intracellular
FGF-1 and FGF-2 levels
Guillonneau et al., Growth Factors 1998
:
In addition,
FGF2 stimulated release of endogenous
FGF1 is associated with reduced apoptosis in RPE cells ... In addition,
FGF2 stimulated the production and release of phosphorylated
FGF1 by RPE cells
Klingenberg et al., J Biol Chem 1998
:
The
aFGF ( K132E ) mutant binds to and
activates fibroblast growth factor receptors equally strongly as the wild-type, but it is a poor mitogen