◀ Back to PIK3R1
FGF2 — PIK3R1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
FGF2
→
PIK3R1
(indirect_complex)
Ong et al., Proc Natl Acad Sci U S A 2001, Guasch et al., Mol Cell Biol 2001, Demiroglu et al., Blood 2001, Agazie et al., Oncogene 2003, Chen et al., Proc Natl Acad Sci U S A 2004, Takeda et al., Clin Cancer Res 2007, Kunii et al., Cancer Res 2008, Byron et al., Cancer Res 2008, Taylor et al., J Clin Invest 2009, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998
-
Reactome Reaction:
FGF2
→
PIK3R1
(reaction)
Ong et al., Proc Natl Acad Sci U S A 2001, Guasch et al., Mol Cell Biol 2001, Demiroglu et al., Blood 2001, Agazie et al., Oncogene 2003, Chen et al., Proc Natl Acad Sci U S A 2004, Takeda et al., Clin Cancer Res 2007, Kunii et al., Cancer Res 2008, Byron et al., Cancer Res 2008, Taylor et al., J Clin Invest 2009, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Ebner et al., J Neurosci Res 2000
:
We demonstrate that
PI3K and Akt ( Ser-473 phosphorylation ) are activated in
response to platelet derived growth factor but not basic
fibroblast growth factor-2 ( FGF2 ) and that distinct forms of PI3K are activated in early progenitors and later-maturation pro-oligodendroblasts as identified by their sensitivity to wortmannin ... Our results therefore demonstrate that
PI3K-Akt signaling independently regulates proliferation and survival, that the form of PI3K is distinct in early progenitors and pro-oligodendroblasts, and that
FGF2 does not
activate this pathway in either primary glial cell population
Chaudhary et al., J Cell Biochem 2001
:
Wortmannin ( 500 nM ), a specific inhibitor of phosphatidylinositol 3-kinase ( PI 3-K), inhibited the activation of ERK1 and ERK2 by PDGF-BB but not by FGF-2 suggesting that
PI 3-K mediated the activation of ERK MAPK pathway by PDGF-BB but not by
FGF-2
Debiais et al., Exp Cell Res 2004
:
FGF-2 increased
PI3K activity but did not induce phosphorylation of Akt or the downstream effector p70 S6 kinase ... The results indicate that the immediate protective
effect of
FGF-2 on human osteoblastic cell apoptosis involves
PI3K and inhibition of downstream caspases, independently of GSK-3 and beta-catenin-Lef/Tcf mediated transcription
Kang et al., Stem Cells Dev 2005
:
bFGF did not
induce activation of
PI3K or PKC, but induced activation of ERK ( extracellular signal regulated kinase )
Cao et al., Am J Physiol Cell Physiol 2006
:
Thrombin also induced the expression of
FGF-2 in a
PI3K-Akt-Fra-1 dependent and mTOR independent manner, and neutralizing anti-FGF-2 antibodies inhibited thrombin stimulated VSMC DNA synthesis and motility
Lu et al., Diabetes 2008
(Diabetes Mellitus, Type 2) :
Inhibition of
PI3K with wortmannin or suppression of Akt activation with dominant negative Akt
inhibited FGF2 expression
Koyama et al., Dev Growth Differ 2008
:
However,
FGF7 and FGF10
stimulated phosphorylation of both PLCgamma1 and
PI3K , but elicited only minimal phosphorylation of ERK-1/2
Maffucci et al., PloS one 2009
:
We further demonstrate that
FGF-2 activates
PI3K , assessed by analysing accumulation of its lipid product phosphatidylinositol-3,4,5-P ( 3 ) using TLC and confocal microscopy analysis
Lawson et al., Proc Natl Acad Sci U S A 2010
(Disease Models, Animal...) :
Stromal induction of
FGF signaling, increased expression of the ETS family transcription factor ERG1, and constitutive
activation of
PI3K signaling were evaluated
Dey et al., Cancer Res 2010
(Lung Neoplasms...) :
Targeting
fibroblast growth factor receptors
blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis
Ding et al., J Cell Physiol 2010
:
These results suggest that
FGF-2 mediated
PI3-K signaling may have a direct role in modulating the downstream of Wnt pathway to maintain undifferentiated hESC
Wang et al., Clin Exp Allergy 2012
:
The
PI3K-specific inhibitor LY294002 also completely
attenuated IL-25 induced
bFGF expression
Sauer et al., Stem Cells Dev 2013
:
In conclusion, a2M stimulates endothelial and early cardiac, but not smooth muscle differentiation of ES cells through generation of NO,
activation of ERK1/2 as well as
PI3K , and induction of
FGF-2 expression