Gene interactions and pathways from curated databases and text-mining

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FGF2 — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Ebner et al., J Neurosci Res 2000 : We demonstrate that PI3K and Akt ( Ser-473 phosphorylation ) are activated in response to platelet derived growth factor but not basic fibroblast growth factor-2 ( FGF2 ) and that distinct forms of PI3K are activated in early progenitors and later-maturation pro-oligodendroblasts as identified by their sensitivity to wortmannin ... Our results therefore demonstrate that PI3K-Akt signaling independently regulates proliferation and survival, that the form of PI3K is distinct in early progenitors and pro-oligodendroblasts, and that FGF2 does not activate this pathway in either primary glial cell population
Chaudhary et al., J Cell Biochem 2001 : Wortmannin ( 500 nM ), a specific inhibitor of phosphatidylinositol 3-kinase ( PI 3-K), inhibited the activation of ERK1 and ERK2 by PDGF-BB but not by FGF-2 suggesting that PI 3-K mediated the activation of ERK MAPK pathway by PDGF-BB but not by FGF-2
Debiais et al., Exp Cell Res 2004 : FGF-2 increased PI3K activity but did not induce phosphorylation of Akt or the downstream effector p70 S6 kinase ... The results indicate that the immediate protective effect of FGF-2 on human osteoblastic cell apoptosis involves PI3K and inhibition of downstream caspases, independently of GSK-3 and beta-catenin-Lef/Tcf mediated transcription
Kang et al., Stem Cells Dev 2005 : bFGF did not induce activation of PI3K or PKC, but induced activation of ERK ( extracellular signal regulated kinase )
Cao et al., Am J Physiol Cell Physiol 2006 : Thrombin also induced the expression of FGF-2 in a PI3K-Akt-Fra-1 dependent and mTOR independent manner, and neutralizing anti-FGF-2 antibodies inhibited thrombin stimulated VSMC DNA synthesis and motility
Lu et al., Diabetes 2008 (Diabetes Mellitus, Type 2) : Inhibition of PI3K with wortmannin or suppression of Akt activation with dominant negative Akt inhibited FGF2 expression
Koyama et al., Dev Growth Differ 2008 : However, FGF7 and FGF10 stimulated phosphorylation of both PLCgamma1 and PI3K , but elicited only minimal phosphorylation of ERK-1/2
Maffucci et al., PloS one 2009 : We further demonstrate that FGF-2 activates PI3K , assessed by analysing accumulation of its lipid product phosphatidylinositol-3,4,5-P ( 3 ) using TLC and confocal microscopy analysis
Lawson et al., Proc Natl Acad Sci U S A 2010 (Disease Models, Animal...) : Stromal induction of FGF signaling, increased expression of the ETS family transcription factor ERG1, and constitutive activation of PI3K signaling were evaluated
Dey et al., Cancer Res 2010 (Lung Neoplasms...) : Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis
Ding et al., J Cell Physiol 2010 : These results suggest that FGF-2 mediated PI3-K signaling may have a direct role in modulating the downstream of Wnt pathway to maintain undifferentiated hESC
Wang et al., Clin Exp Allergy 2012 : The PI3K-specific inhibitor LY294002 also completely attenuated IL-25 induced bFGF expression
Sauer et al., Stem Cells Dev 2013 : In conclusion, a2M stimulates endothelial and early cardiac, but not smooth muscle differentiation of ES cells through generation of NO, activation of ERK1/2 as well as PI3K , and induction of FGF-2 expression