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CBL — FGFR2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fong et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
In this study it is demonstrated that hSpry2 is tyrosine phosphorylated upon
stimulation by either
FGFR or EGF and subsequently binds endogenous
c-Cbl with high affinity
Kaabeche et al., J Cell Sci 2005
(Acrocephalosyndactylia) :
We show that
Cbl recruitment
induced by
FGFR2 activation triggers alpha5 integrin degradation by the proteasome, which results in reduced osteoblast attachment on fibronectin and caspase dependent apoptosis
Dufour et al., Bone 2008
:
FGFR2 activation
increases FGFR2 and
Cbl recruitment in micro-domains, resulting in increased molecular interactions