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FKBP4 — HSP90AA1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (monomer) complex (NR3C1) → cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) (translocation, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: assay
• NCI Pathway Database Glucocorticoid receptor regulatory network: Hsp90 (HSP90AA1) → FKBP52 (FKBP4) (translocation, collaborate) Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: assay
• NCI Pathway Database Glucocorticoid receptor regulatory network: Hsp90 (HSP90AA1) → cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) (translocation, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: assay
• NCI Pathway Database Glucocorticoid receptor regulatory network: FKBP52 (FKBP4) → cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) (translocation, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: assay
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) → Hsp90 (HSP90AA1) (translocation, collaborate) Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: assay
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) → cortisol/GR alpha (dimer) complex (NR3C1) (translocation, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: assay
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) → FKBP52 (FKBP4) (translocation, collaborate) Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: assay
• NCI Pathway Database Glucocorticoid receptor regulatory network: Hsp90 (HSP90AA1) → FKBP52 (FKBP4) (translocation, collaborate) Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: assay
• NCI Pathway Database Glucocorticoid receptor regulatory network: None → cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) (modification, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: None → cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) (modification, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) → FKBP51 (FKBP5) (modification, collaborate) Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) → cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) (modification, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) → FKBP52 (FKBP4) (modification, collaborate) Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) → GR alpha/HSP90/FKBP51/HSP90 complex (NR3C1-HSP90AA1-FKBP5) (modification, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: FKBP51 (FKBP5) → cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) (modification, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) → FKBP52 (FKBP4) (modification, collaborate) Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 complex (NR3C1-HSP90AA1-FKBP4) → GR alpha/HSP90/FKBP51/HSP90 complex (NR3C1-HSP90AA1-FKBP5) (modification, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: FKBP52 (FKBP4) → GR alpha/HSP90/FKBP51/HSP90 complex (NR3C1-HSP90AA1-FKBP5) (modification, collaborate)
  Davies et al., J Biol Chem 2002, de Castro et al., Mol Med 1996*
  Evidence: physical interaction
• Reactome Reaction: FKBP4 → HSP90AA1 (indirect_complex) Guo et al., J Biol Chem 2001*, Nair et al., Cell Stress Chaperones 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FKBP4 — HSP90AA1 (physical association, affinity chromatography technology) Esposito et al., J Cell Biochem 2012*
• IRef Biogrid Interaction: FKBP4 — HSP90AA1 (physical association, affinity chromatography technology) Schülke et al., PloS one 2010
• IRef Biogrid Interaction: FKBP4 — HSP90AA1 (physical association, affinity chromatography technology) Kristensen et al., Nat Methods 2012
• IRef Biogrid Interaction: FKBP4 — HSP90AA1 (physical association, affinity chromatography technology) Gano et al., Mol Cell Proteomics 2010
• IRef Biogrid Interaction: FKBP4 — HSP90AA1 (physical association, affinity chromatography technology) Skarra et al., Proteomics 2011
• IRef Biogrid Interaction: FKBP4 — HSP90AA1 (direct interaction, pull down) Shimamoto et al., FEBS Lett 2010*
• IRef Biogrid Interaction: FKBP4 — HSP90AA1 (physical association, affinity chromatography technology) Shimamoto et al., FEBS Lett 2010*
• IRef Biogrid Interaction: FKBP4 — HSP90AA1 (direct interaction, pull down) Li et al., Nature structural & molecular biology 2011
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Guo et al., J Biol Chem 2001*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Davies et al., J Biol Chem 2002
• IRef Intact Interaction: Complex of 33 proteins (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010
• IRef Intact Interaction: Complex of 29 proteins (association, anti tag coimmunoprecipitation) Skarra et al., Proteomics 2011
• IRef Intact Interaction: Complex of 203 proteins (association, cross-linking study) Byron et al., Proteomics 2012
• IRef Intact Interaction: FKBP4 — HSP90AA1 (direct interaction, pull down) Shimamoto et al., FEBS Lett 2010*
• IRef Intact Interaction: Complex of HSP90AA1-FKBP4 (association, anti tag coimmunoprecipitation) Shimamoto et al., FEBS Lett 2010*
• IRef Intact Interaction: Complex of S100A2-FKBP4-HSP90AA1 (association, anti tag coimmunoprecipitation) Shimamoto et al., FEBS Lett 2010*
• IRef Intact Interaction: Complex of S100A6-FKBP4-HSP90AA1 (association, anti tag coimmunoprecipitation) Shimamoto et al., FEBS Lett 2010*
• IRef Intact Interaction: Complex of 29 proteins (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010
• IRef Intact Interaction: Complex of 46 proteins (association, tandem affinity purification) Gano et al., Mol Cell Proteomics 2010

Text-mined interactions from Literome

Chadli et al., Biochemistry 2008 : We now show that FKBP52 is also able to bind to this site, and that these two cochaperones act competitively, through Hsp90 , to modulate PR activity
Jinwal et al., J Neurosci 2010 : FKB51 enhances the association of tau with Hsp90, but the FKBP51/tau interaction is not dependent on Hsp90