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EPHB2 — FLT1

Text-mined interactions from Literome

Kato et al., Biochem Biophys Res Commun 2001 : Although SPARC derived peptide showed an angiogenic effect, intact SPARC itself inhibited the mitogenic activity of vascular endothelial growth factor ( VEGF ) for ECs by the inhibiting phosphorylation of flt-1 ( VEGF receptor 1 ) and subsequent ERK activation
Lichtenberger et al., Cell 2010 (Carcinoma, Squamous Cell...) : Mechanistically, K5-SOS upregulates VEGF, Flt1 , and Neuropilin-1 in an Erk dependent manner, thereby activating an autocrine proliferation loop, whereas EGFR prevents tumor cells from apoptosis
Boscolo et al., Am J Pathol 2011 (Cell Transformation, Neoplastic...) : We report here that VEGF-A or VEGF-B induces VEGFR-1 mediated ERK1/2 phosphorylation in HemSCs and promotes differentiation of HemSCs to endothelial cells ... Furthermore, the down-regulation of VEGFR-1 in the HemSCs results in decreased formation of blood vessels in vivo and reduced ERK1/2 activation
Ho et al., Circulation 2012 (Cardiomyopathies) : VEGFR-1 knockout led to abundant accumulation of VEGFR-2 at the protein level, increased VEGFR-2 tyrosine phosphorylation transiently, and enhanced serine phosphorylation of Akt and ERK