Gene interactions and pathways from curated databases and text-mining

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FOXO1 — PIK3R1

Text-mined interactions from Literome

Richards et al., Mol Endocrinol 2002 : In naïve granulosa cells, both FSH and IGF-I stimulate rapid phosphorylation of FKHR at multiple sites causing its redistribution from the nucleus to the cytoplasm in a PI3K dependent manner
Morrison et al., J Virol 2003 : LMP2A activated Akt in a PI3K dependent manner, and the downstream Akt targets glycogen synthase kinase 3beta ( GSK3beta ) and the Forkhead transcription factor FKHR were phosphorylated and inactivated in LMP2A expressing HFK cells
Schwab et al., Apoptosis 2005 (Neuroblastoma) : PI3-K inhibitor, LY294002, reduced IGF-I stimulated phosphorylation of FKHR , FKHRL1, and Akt, but did not affect Erk phosphorylation
Reagan-Shaw et al., Cancer Res 2006 (Breast Neoplasms...) : Further, our data showed that PI3K knockdown resulted in a significant activation of FoxO ; interestingly, a simultaneous knockdown of FoxO1a rescued the cells from apoptosis
Martinez et al., Diabetes 2006 : The use of inhibitors demonstrated that glucose induced Foxo1 phosphorylation was dependent upon depolarization, calcium influx, and PI3K signaling
Lavery et al., J Neurosci 2007 : Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a Ras-PI3K-Akt dependent inhibition of FOXO within Schwann cells
Lengyel et al., Steroids 2007 : The present work shows that PI3K plays a crucial role in the phosphorylation and inactivation of FOXO1 in vivo, indicating that the regulation of this transcription factor is a more complex event in uterine cells requiring further investigations
Abid et al., Arterioscler Thromb Vasc Biol 2008 : Incubation of human coronary artery endothelial cells with HGF induced prolonged PI3K/Akt dependent phosphorylation and nuclear exclusion of FKHR/FOXO1
Howlett et al., PLoS Genet 2008 : In humans, PI3K and group II mGluRs are implicated in epilepsy, neurofibromatosis, autism, schizophrenia, and other neurological disorders ; however, neither the link between group II mGluRs and PI3K, nor the role of PI3K dependent regulation of Foxo in the control of neuronal excitability, had been previously reported
Park et al., Cell Signal 2009 : In this study, we found that TRAIL inhibited PI3K/Akt dependent FoxO phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells
Goertz et al., J Clin Invest 2011 (Infertility, Male) : By conditional inactivation of 3-phosphoinositide dependent protein kinase 1 ( Pdk1 ) and phosphatase and tensin homolog (Pten) in the male germ line, we found that PI3K signaling regulates Foxo1 stability and subcellular localization, revealing that the Foxos are pivotal effectors of PI3K-Akt signaling in SSCs
Tabassam et al., Helicobacter 2012 (Helicobacter Infections) : Inhibition of PI3K or Akt kinase activity reduced FoxO1/3a phosphorylation ... Infection with oipA mutants reduced PI3K/Akt activation and inhibited FoxO1/3a phosphorylation, whereas infection with cag PAI mutants reduced PI3K/Akt activity but did not inhibit FoxO1/3a activation
Mahajan et al., Thromb Haemost 2012 : In conclusion, thrombin and FoxO factors functionally interact through PI3K/Akt dependent FoxO phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation
Arriola et al., J Biol Chem 2012 : We demonstrated that FOXO1 is expressed in murine gonadotrope cells and that insulin signaling increased FOXO1 phosphorylation and cytoplasmic localization in a PI3K dependent manner