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FOXO3 — PIK3R1
Text-mined interactions from Literome
Dijkers et al., Mol Cell Biol 2000
:
This transcriptional regulation occurs through modulation of the forkhead transcription factor FKHR-L1, and IL-3 inhibited
FKHR-L1 activity in a
PI3K dependent manner ... Taken together, these observations indicate that inhibition of p27 ( KIP1 ) transcription through
PI3K induced
FKHR-L1 phosphorylation provides a novel mechanism of regulating cytokine mediated survival and proliferation
Chandramohan et al., J Immunol 2004
:
We demonstrate that pharmacologic inhibitors of
PI3K or BCR engagement lead to decreased inactive cytoplasmic levels and
increased active functional nuclear
FOXO3a
Schwab et al., Apoptosis 2005
(Neuroblastoma) :
PI3-K inhibitor, LY294002,
reduced IGF-I stimulated phosphorylation of FKHR,
FKHRL1 , and Akt, but did not affect Erk phosphorylation
Tjin et al., Blood 2006
(Lymphoma, B-Cell...) :
In MET positive DLBCL cells, HGF induces MEK dependent activation of ERK and
PI3K dependent phosphorylation of PKB, GSK3, and
FOXO3a
Kumar et al., Mol Cell Biol 2006
(Cell Transformation, Neoplastic) :
In addition, we show that Galpha12QL stimulates the phosphorylation of forkhead transcription factor
FKHRL1 via AKT in a PDGFRalpha- and
PI3K dependent manner
Reagan-Shaw et al., Cancer Res 2006
(Breast Neoplasms...) :
Further, our data showed that
PI3K knockdown
resulted in a significant activation of
FoxO ; interestingly, a simultaneous knockdown of FoxO1a rescued the cells from apoptosis
Lavery et al., J Neurosci 2007
:
Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a
Ras-PI3K-Akt dependent inhibition of
FOXO within Schwann cells
John et al., Dev Biol 2008
:
Oocyte-specific ablation of Pten resulted in
PI3K induced Akt activation, Foxo3 hyperphosphorylation, and
Foxo3 nuclear export, thereby triggering primordial follicle activation, defining the steps by which the PI3K pathway and Foxo3 control this process
Howlett et al., PLoS Genet 2008
:
In humans, PI3K and group II mGluRs are implicated in epilepsy, neurofibromatosis, autism, schizophrenia, and other neurological disorders ; however, neither the link between group II mGluRs and PI3K, nor the role of
PI3K dependent regulation of
Foxo in the control of neuronal excitability, had been previously reported
Kok et al., Trends Biochem Sci 2009
(Neoplasms) :
Recently identified mechanisms that control PI3K production include increased gene copy number in cancer, and transcriptional
regulation of the p110alpha
PI3K gene by
FOXO3a , NF-kappaB and p53, and of the PI3K regulatory subunits by STAT3, EBNA-2 and SREBP
Park et al., Cell Signal 2009
:
In this study, we found that TRAIL inhibited
PI3K/Akt dependent
FoxO phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells
Weidinger et al., J Clin Endocrinol Metab 2011
(Carcinoma...) :
FOXO3 is
inhibited by oncogenic
PI3K/Akt signaling but can be reactivated by the NSAID sulindac sulfide
Mahajan et al., Thromb Haemost 2012
:
In conclusion, thrombin and FoxO factors functionally interact through
PI3K/Akt dependent
FoxO phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation
Tenbaum et al., Nat Med 2012
(Colonic Neoplasms...) :
Simultaneous hyperactivation of the Wnt-ß-catenin pathway and inhibition of
PI3K-AKT signaling
promote nuclear accumulation of ß-catenin and
FOXO3a , respectively, promoting cell scattering and metastasis by regulating a defined set of target genes ... In the presence of high nuclear ß-catenin content,
activation of
FOXO3a by
PI3K or AKT inhibitors makes it behave as a metastasis inductor rather than a proapoptotic tumor suppressor
Qi et al., J Biol Chem 2013
(Colonic Neoplasms) :
Stimulation of LD density in human colon cancer cells led to a
PI3K dependent loss of
FOXO3 and a decrease in the negative regulator of lipid metabolism in Sirtuin6 (SIRT6)
Uranga et al., J Biol Chem 2013
:
Levels of
phospho-FoxO3a ( inactive form ) increased in the cytosolic fraction of cells treated with iron in a
PI3K dependent manner
Shoeb et al., Free Radic Biol Med 2013
(Colonic Neoplasms) :
We found that AR inhibition regulates
AKT/PI3K dependent
activation of forkhead transcription factor
FOXO3a