Gene interactions and pathways from curated databases and text-mining

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EGFR — FYN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

  • STRING interaction: EGFR — FYN (interaction, mapped from kegg_pathways)
  • STRING interaction: EGFR — FYN (interaction, mapped from kegg_pathways)
  • STRING interaction: FYN — EGFR (interaction, mapped from kegg_pathways)
  • STRING interaction: FYN — EGFR (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Sabri et al., Circ Res 2002 : Activation of PAR-1 leads to an increase in Src, Fyn , and epidermal growth factor receptor (EGFR) phosphorylation, with EGFR receptor transactivation by Src family kinases the major mechanism for PAR-1 dependent activation of extracellular signal regulated kinase, p38-mitogen activated protein kinase, and protein kinase B
Reinehr et al., J Biol Chem 2004 : PP-2 abolished the hyperosmotic activation of Fyn and Lck but not activation of Yes and EGFR and their association
Shiraishi et al., Endocrinology 2006 : The LHR mediated phosphorylation of the EGFR and Shc, the activation of Ras, and the phosphorylation of ERK1/2 are inhibited by expression of a dominant negative mutant of Fyn , a member of the Src family kinases (SFKs) expressed in MA-10 cells and by PP2, a pharmacological inhibitor of the SFKs
Shiraishi et al., Exp Cell Res 2008 : Transfection of interfering constructs shows that the LHR mediated activation of Fyn in MA-10 cells is necessary for the phosphorylation of the EGFR and ERK1/2 in I-10 cells
Yadav et al., Mol Carcinog 2011 : Activation of Akt, but not MAPK or EGFR , was necessary and sufficient for induction of Fyn by H-Ras