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EGFR — FYN
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
EGFR
—
FYN
(interaction, mapped from kegg_pathways)
-
STRING interaction:
EGFR
—
FYN
(interaction, mapped from kegg_pathways)
-
STRING interaction:
FYN
—
EGFR
(interaction, mapped from kegg_pathways)
-
STRING interaction:
FYN
—
EGFR
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Sabri et al., Circ Res 2002
:
Activation of PAR-1 leads to an
increase in Src,
Fyn , and epidermal growth factor receptor (EGFR) phosphorylation, with
EGFR receptor transactivation by Src family kinases the major mechanism for PAR-1 dependent activation of extracellular signal regulated kinase, p38-mitogen activated protein kinase, and protein kinase B
Reinehr et al., J Biol Chem 2004
:
PP-2 abolished the hyperosmotic activation of
Fyn and Lck but not
activation of Yes and
EGFR and their association
Shiraishi et al., Endocrinology 2006
:
The LHR mediated phosphorylation of the
EGFR and Shc, the activation of Ras, and the phosphorylation of ERK1/2 are
inhibited by expression of a dominant negative mutant of
Fyn , a member of the Src family kinases (SFKs) expressed in MA-10 cells and by PP2, a pharmacological inhibitor of the SFKs
Shiraishi et al., Exp Cell Res 2008
:
Transfection of interfering constructs shows that the LHR mediated activation of
Fyn in MA-10 cells is
necessary for the phosphorylation of the
EGFR and ERK1/2 in I-10 cells
Yadav et al., Mol Carcinog 2011
:
Activation of Akt, but not MAPK or
EGFR , was
necessary and sufficient for induction of
Fyn by H-Ras