◀ Back to PIK3R1
GAB1 — PIK3R1
Pathways - manually collected, often from reviews:
-
KEGG Neurotrophin signaling pathway:
GAB1
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, binding/association)
-
KEGG Bacterial invasion of epithelial cells:
GAB1
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Renal cell carcinoma:
GAB1
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG ErbB signaling pathway:
GAB1
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/GRB2/SOS1/GAB1/PI3K complex (SHC1-GRB2-SOS1-GAB1-PIK3CA-PIK3R1)
→
SHC/GRB2/SOS1/GAB1 complex (SHC1-GRB2-SOS1-GAB1)
(modification, collaborate)
Obermeier et al., EMBO J 1993, Cunningham et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/GRB2/SOS1/GAB1/PI3K complex (SHC1-GRB2-SOS1-GAB1-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Obermeier et al., EMBO J 1993, Cunningham et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/GRB2/SOS1/GAB1 complex (SHC1-GRB2-SOS1-GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Obermeier et al., EMBO J 1993, Cunningham et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events mediated by Stem cell factor receptor (c-Kit):
Gab1 (GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, inhibits)
-
NCI Pathway Database IL6-mediated signaling events:
GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1)
→
AKT1 (AKT1)
(modification, activates)
Jee et al., J Invest Dermatol 2002
Evidence: mutant phenotype
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Yu et al., J Biol Chem 2001, Yu et al., J Biol Chem 2002*, Graziani et al., J Biol Chem 1991*, Schaeper et al., Proc Natl Acad Sci U S A 2007, Ponzetto et al., Cell 1994
Evidence: assay, physical interaction
-
NCI Pathway Database LPA receptor mediated events:
Gab1 (GAB1)
→
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
Gab1 (GAB1)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
→
EGFR (EGFR)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma:
None
→
SHC/GRB2/SOS1/GAB1/PI3K complex (SHC1-GRB2-SOS1-GAB1-PIK3CA-PIK3R1)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
Gab1 (GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Caron et al., Cell Signal 2009*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
Gab1 (GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Carmeliet et al., Cell 1999, Chabot et al., Mol Cell Biol 2009*
Evidence: physical interaction
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
→
None
(modification, activates)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
(modification, activates)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPO signaling pathway:
SHC (SHC1)
→
GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1)
(modification, collaborate)
-
NCI Pathway Database EPO signaling pathway:
Gab1 (GAB1)
→
GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1)
(modification, collaborate)
-
NCI Pathway Database EPO signaling pathway:
Gab1 (GAB1)
→
PIK3R1 (PIK3R1)
(modification, collaborate)
-
NCI Pathway Database EPO signaling pathway:
GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1)
→
PIK3R1 (PIK3R1)
(modification, collaborate)
-
NCI Pathway Database EPO signaling pathway:
GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1)
→
SHP2 (PTPN11)
(modification, collaborate)
-
NCI Pathway Database EPO signaling pathway:
GAB1/SHIP/PIK3R1/SHP2/SHC complex (GAB1-INPP5D-PIK3R1-PTPN11-SHC1)
→
SHIP (INPP5D)
(modification, collaborate)
-
NCI Pathway Database IL6-mediated signaling events:
GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Takahashi-Tezuka et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11)
→
GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, collaborate)
Takahashi-Tezuka et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, collaborate)
Takahashi-Tezuka et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
PIK3R1
→
GAB1
(indirect_complex)
Rodrigues et al., Mol Cell Biol 2000, Jackson et al., Cancer Res 2004, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
-
Reactome Reaction:
PIK3R1
→
GAB1
(direct_complex)
Onishi-Haraikawa et al., Biochem Biophys Res Commun 2001*
-
Reactome Reaction:
PIK3R1
→
GAB1
(reaction)
Onishi-Haraikawa et al., Biochem Biophys Res Commun 2001*, Jackson et al., Cancer Res 2004
-
WikiPathways Signaling Pathways in Glioblastoma:
GAB1
→
Complex of PIK3R1-PIK3R2-PIK3CA-PIK3CB-PIK3CD
(mim-stimulation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
GAB1
—
PIK3R1
(physical association, affinity chromatography technology)
Holgado-Madruga et al., Nature 1996*
-
IRef Biogrid Interaction:
GAB1
—
PIK3R1
(direct interaction, far western blotting)
Holgado-Madruga et al., Nature 1996*
-
IRef Biogrid Interaction:
GAB1
—
PIK3R1
(direct interaction, two hybrid)
Rocchi et al., Mol Endocrinol 1998*
-
IRef Biogrid Interaction:
GAB1
—
PIK3R1
(physical association, affinity chromatography technology)
Ingham et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
GAB1
—
PIK3R1
(direct interaction, far western blotting)
Ingham et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
GAB1
—
PIK3R1
(direct interaction, pull down)
Bertagnolo et al., FEBS Lett 1998*
-
IRef Hprd Interaction:
GAB1
—
PIK3R1
(in vitro)
Saito et al., J Biol Chem 2002*, Hanna et al., FEBS Lett 2006*
-
IRef Intact Interaction:
Complex of 37 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
GAB1
—
PIK3R1
(association, pull down)
Lehr et al., Biochemistry 2000*
-
IRef Intact Interaction:
GAB1
—
PIK3R1
(association, coimmunoprecipitation)
Lehr et al., Biochemistry 2000*
-
IRef Intact Interaction:
GAB1
—
PIK3R1
(physical association, pull down)
Hanna et al., FEBS Lett 2006*
-
IRef Intact Interaction:
GAB1
—
PIK3R1
(physical association, two hybrid)
Rocchi et al., Mol Endocrinol 1998*
-
IRef Ophid Interaction:
GAB1
—
PIK3R1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Yart et al., J Biol Chem 2001
:
Indeed, the association of
Gab1 with SHP2 was
blocked by
PI3K inhibitors, and expression of Gab1 mutant deficient for binding to SHP2 was found to inhibit Ras stimulation without interfering with PI3K activation
Ingham et al., J Biol Chem 2001
:
Moreover, using confocal microscopy, we show that BCR ligation can induce the translocation of
Gab1 from the cytosol to the plasma membrane and that this
requires the Gab1 PH domain as well as
PI3K activity
Kojima et al., Exp Hematol 2001
(MAP Kinase Signaling System) :
TPO
induces the association of tyrosine phosphorylated
Gab1 with
p85-PI3K
Yart et al., J Biol Chem 2002
:
Indeed, both membrane redistribution and phosphorylation of
Gab1 were reduced in the
presence of
PI3K inhibitors or dominant negative p110beta
Sampaio et al., Mol Cell Biol 2008
:
Indeed, by up- and down-regulation of signal strength in different cell lines and through different methods, we observed that
Gab1/Shp2 and Ras/ERK1-2 in concert become independent of PI3K upon strong epidermal growth factor receptor (EGFR) stimulation and
dependent on
PI3K upon limited EGFR activation
Maus et al., Cell Signal 2009
:
It has been shown in several model systems that
Gab/Dos family members may
regulate both the anti-apoptotic
PI3-K/Akt and the mitogenic Ras/MAPK pathways, still their role in B-cells have not been investigated in detail
Eulenfeld et al., J Cell Sci 2009
:
We demonstrate that the presence of
PI3K activity in the cell is not
sufficient for binding
Gab1 to the plasma membrane
Zheng et al., J Immunol 2010
:
In addition to promoting both MyD88- and TLR/IL-1 receptor domain containing adaptor protein inducing IFN-beta dependent MAPKs and NF-kappaB activation,
Gab1 enhances
PI3K/Akt activation by directly binding p85 in TLR signaling and VSV infection