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Tucker et al., Helicobacter 2010 (Disease Models, Animal...) : Activation of gastrin through MAPK signaling did not require CagA or VacA virulence factors
Zhou et al., Gastric Cancer 2011 (MAP Kinase Signaling System...) : The results indicated that CagA could activate the gastrin promoter and up-regulate gastrin mRNA expression in AGS and SGC-7901 cells, but these effects could be inhibited by the inhibitors U0126 and AG490, and the CagA induced gastrin mRNA expression was down-regulated in the cells whose ERK1 or JAK2 gene was knocked down ... Gastrin promoter may be the transcriptional target of CagA, and CagA activates the gastrin promoter to up-regulate gastrin mRNA expression through the MEK/ERK and JAK1 signaling pathway in gastric cancer cells
Kim et al., Yonsei Med J 1998 (Gastrointestinal Diseases...) : Serum gastrin and pepsinogen I, II concentrations in children with Helicobacter pylori infection : the role of CagA and VacA