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CISH — GHR

Pathways - manually collected, often from reviews:

• Reactome Reaction: CISH → GHR (indirect_complex)
• Reactome Reaction: CISH → GHR (reaction)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CISH — GHR (physical association, affinity chromatography technology) Ram et al., J Biol Chem 1999*
• IRef Biogrid Interaction: CISH — GHR (direct interaction, pull down) Ram et al., J Biol Chem 1999*
• IRef Hprd Interaction: GHR — CISH (in vitro) Du et al., Endocrinology 2003*
• IRef Hprd Interaction: GHR — CISH (in vivo) Du et al., Endocrinology 2003*
• IRef Innatedb Interaction: GHR — CISH (unknown, -) Ram et al., J Biol Chem 1999*

Text-mined interactions from Literome

Davey et al., Endocrinology 2001 : GH induced the expression of liver Igf-I mRNA in hypophysectomized male wild-type, but not in hypophysectomized male Stat5b ( -/- ) mice, although the Stat5b ( -/- ) mice exhibit both normal liver GH receptor expression and strong GH induction of Cytokine-inducible SH2 protein (Cis) , which is believed to contribute to the down-regulation of GH-induced liver STAT5b signaling
Du et al., Endocrinology 2003 : By 60 min after GH, tyrosine phosphorylation of the GHR declined to very low levels, and its interaction with CIS was reduced correspondingly
Kenth et al., Mol Cell Endocrinol 2011 : Human growth hormone receptor gene expression is regulated by Gfi-1/1b and GAGA cis-elements