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GJA1 — PIK3R1
Text-mined interactions from Literome
Luo et al., J Gene Med 2007
(Carcinoma) :
The PKA and
PI3K signal transduction pathways are likely
involved in enhanced
Cx43 expression as inhibitors of these pathways prevented Cx43 upregulation
Yao et al., Ophthalmic Res 2008
:
The activation of
PI3K/Akt was
necessary for the TGF-beta(2) stimulated downregulation of
connexin 43 , which in turn was necessary for TGF-beta2 induced EMT in HLEB-3 cells
Tacheau et al., J Cell Physiol 2008
:
Using specific pharmacologic inhibitors for JNK, ERK, p38, and PI3K/AKT signaling pathways, we demonstrated the cooperative
role of p38 and
PI3K/AKT signaling in TGF-beta1 induced
Cx43 expression and gap junctional communication
Bhattacharjee et al., Biochem Biophys Res Commun 2009
:
These results suggest an important
role of
PI3K/Akt in the regulation of basal
Cx43 expression
Kim et al., J Cell Physiol 2010
:
We conclude that NECA stimulated
Cx43 phosphorylation
mediated by
PI3K/Akt , PKC, MAPKs, and NF-kappaB, which subsequently stimulated cell migration and proliferation through Src, integrin beta1, FAK, and paxillin signal pathways