Wu et al., Circ Res 2000
(Acidosis) :
We have ruled out the possibilities that the AA-induced acidosis is caused by ( 1 ) inhibition or stimulation of the pH(i) regulators, ( 2 ) protein kinase C activation or the generation of AA metabolites or free radicals, or ( 3 ) activation of NADPH oxidase or an inward H ( + ) current
Muzaffar et al., Prostaglandins Leukot Essent Fatty Acids 2008
:
NO and PGI ( 2 ) block the acute activity of NOX in hVSMCs via the cGMP-PKG axis ( for NO ) and by the cAMP-PKA axis ( for iloprost ) through inhibition of Rac(1) and p47(phox) translocation