Gene interactions and pathways from curated databases and text-mining

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GRAP2 — PIK3R1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Gonzalez-Robayna et al., Mol Endocrinol 2000 : Lastly, FSH mediated phosphorylation of p38MAPK is negatively affected by A kinase and PI3-K , suggesting that it may be downstream of specific members of the cAMP-GEF/Rap/Raf pathway
Patel et al., Diabetes 2003 : None of the inhibitors significantly inhibited protein content over 20 days, but lipid content and lipogenic activity were inhibited by p70 ( S6 ) kinase and p38 MAPK inhibition but not by p42/44 MAPK or PI3K inhibition
Pasapera et al., J Steroid Biochem Mol Biol 2005 : Transactivation of estrogen-sensitive genes by FSH or PKA activators were blocked ( approximately 90 % ) by H89 ( PKA inhibitor ) and LY294002 but not by Wortmannin ( PI3-K inhibitors ), 4-OH-tamoxifen, ICI182,780 or SB203580 ( p38 MAPK inhibitor ) ; PD98059 ( ERK1/2 inhibitor ) partially ( approximately 30 % ) blocked the FSH mediated effect
Vanni et al., Cell cycle (Georgetown, Tex.) 2006 : Furthermore, we investigated the signaling molecules involved in proto-Dbl induced cell transformation and motility and observed that inhibition of PI3K in proto-Dbl expressing cells induces an increase in p38 activity and a decrease in ERK phosphorylation
Ruhland et al., Exp Parasitol 2009 : Interestingly, activation of PI3K/Akt signaling had differential effects on ERK and p38 activation
Kulasekaran et al., Am J Respir Cell Mol Biol 2009 (Idiopathic Pulmonary Fibrosis) : ET-1 induced activation of PI3K/AKT is dependent on p38 mitogen activated protein kinase ( MAPK ), but not extracellular signal regulated kinase ( ERK ) 1/2, JNK, or transforming growth factor (TGF)-beta1
Dai et al., J Biol Chem 2012 (Carcinoma, Hepatocellular...) : Both p38 MAPK promoted glucose regulated protein 78 (GRP78) expression and sustained high basal activation of PI3K/Akt and MEK/ERK are involved in the cytoprotective function of p190Met ( NC )
Gao et al., EMBO Mol Med 2012 (Disease Models, Animal...) : This involved p38 MAPK activation by PI3K to facilitate clathrin mediated ErbB receptor endocytosis
Hsieh et al., Chem Biol Interact 2013 (Breast Neoplasms) : Additionally, treatment of SB203580 ( p38 MAPK inhibitor ) or wortmannin ( PI3K inhibitor ) resulted in a reduced activity and expression of MMP-2 as well as inhibition on cell migration and invasion in MDA-MB-231 cells