Gene interactions and pathways from curated databases and text-mining

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GRAP2 — PRKAR2A

Text-mined interactions from Literome

Zhang et al., J Neurochem 1999 (Glioma...) : Inhibition of protein kinase A (PKA) strongly diminished p38 activation mediated by DOR or ORL1 but had no significant effect on ERK activation, and protein kinase C ( PKC ) inhibitors potentiated stimulation of p38 while inhibiting activation of ERKs
Cao et al., J Biol Chem 2001 : The involvement of PKA in beta ( 3 ) AR-dependent p38 MAPK activation was confirmed by the ability of the PKA inhibitors H89 ( 20 microm ) and ( R ( p ) ) -cAMP-S ( 1 mm ) to block phosphorylation of p38 MAPK
Rius et al., Arterioscler Thromb Vasc Biol 2004 (Calcium Signaling...) : The upregulation of NOR-1 mRNA levels by LDL involves pertusis-sensitive G protein coupled receptors, Ca2+ mobilization, protein kinases A (PKA) and C ( PKC ) activation , and mitogen activated protein kinase pathways ( MAPK ) ( p44/p42 and p38 )
Pasapera et al., J Steroid Biochem Mol Biol 2005 : Transactivation of estrogen-sensitive genes by FSH or PKA activators were blocked ( approximately 90 % ) by H89 ( PKA inhibitor ) and LY294002 but not by Wortmannin ( PI3-K inhibitors ), 4-OH-tamoxifen, ICI182,780 or SB203580 ( p38 MAPK inhibitor ) ; PD98059 ( ERK1/2 inhibitor ) partially ( approximately 30 % ) blocked the FSH mediated effect
Launay et al., Exp Cell Res 2006 : Upstream of p38, we found that RhoK, PKC and PKA are selectively involved in the activation of p38 and phosphorylation of alphaB-crystallin, depending on the cytoskeletal network disorganized
Saha et al., Pigment Cell Res 2006 : Moreover, we also show that activation of p38 mediated by lipids is potentiated by inhibition of the PI3kinase pathway but not by inhibition of protein kinase A (PKA)
Chen et al., Cancer Res 2007 (Breast Neoplasms) : Specific activation of protein kinase A (PKA) or EPAC with cAMP analogues stimulated p38 and JNK1 ; however, only PKA activating cAMP analogues induced aromatase expression
Somvanshi et al., Int J Cardiol 2013 (Cardiomegaly) : SST enhances ß2AR agonist formoterol mediated effects on PKA , CREB and ERK1/2 phosphorylations whereas it inhibits isoproterenol mediated ERK1/2 and p38 signaling in concentration dependent manner