◀ Back to PIK3R1
GRB2 — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/GRB2/SOS1/GAB1/PI3K complex (SHC1-GRB2-SOS1-GAB1-PIK3CA-PIK3R1)
→
SHC/GRB2/SOS1/GAB1 complex (SHC1-GRB2-SOS1-GAB1)
(modification, collaborate)
Obermeier et al., EMBO J 1993, Cunningham et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/GRB2/SOS1/GAB1/PI3K complex (SHC1-GRB2-SOS1-GAB1-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Obermeier et al., EMBO J 1993, Cunningham et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/GRB2/SOS1/GAB1 complex (SHC1-GRB2-SOS1-GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Obermeier et al., EMBO J 1993, Cunningham et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2 signaling events mediated by PI3K:
None
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, collaborate)
Augustine et al., Mol Cell Biol 1991, Gómez et al., J Immunol 1997
Evidence: assay, other species
-
NCI Pathway Database IL2 signaling events mediated by PI3K:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
PKC zeta (PRKCZ)
(modification, activates)
Gómez et al., Exp Cell Res 1995, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database VEGFR3 signaling in lymphatic endothelium:
SHC/GRB2/SOS1 complex (SOS1-GRB2-SHC1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Mäkinen et al., EMBO J 2001, Salameh et al., Blood 2005
Evidence: assay
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database SHP2 signaling:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database SHP2 signaling:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database SHP2 signaling:
PI3K complex (PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1)
→
AKT1 (AKT1)
(modification, activates)
Jee et al., J Invest Dermatol 2002
Evidence: mutant phenotype
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/Shank3/Grb2 complex (RET-SHANK3-GRB2-GFRA1-GDNF)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Schuetz et al., J Cell Biol 2004
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma:
None
→
SHC/GRB2/SOS1/GAB1/PI3K complex (SHC1-GRB2-SOS1-GAB1-PIK3CA-PIK3R1)
(modification, collaborate)
-
NCI Pathway Database IL2 signaling events mediated by PI3K:
None
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Gu et al., Mol Cell Biol 2000, Lindemann et al., J Biol Chem 2003, Akbar et al., Eur J Immunol 1996, Ahmed et al., Proc Natl Acad Sci U S A 1997, Reif et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2 signaling events mediated by STAT5:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
STAT5 (dimer)-active (STAT5B/STAT5A)
(transcription, activates)
Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
RAF1 (RAF1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype, other species
-
NCI Pathway Database SHP2 signaling:
RAF1 (RAF1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype
-
NCI Pathway Database IL6-mediated signaling events:
GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Takahashi-Tezuka et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11)
→
GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, collaborate)
Takahashi-Tezuka et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, collaborate)
Takahashi-Tezuka et al., Mol Cell Biol 1998
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
GRB2
→
PIK3R1
(reaction)
Nishida et al., Blood 1999, Wickrema et al., J Biol Chem 1999, Onishi-Haraikawa et al., Biochem Biophys Res Commun 2001*, Demiroglu et al., Blood 2001, Sattler et al., Cancer Cell 2002*, Roumiantsev et al., Cancer Cell 2004, Jackson et al., Cancer Res 2004, Yu et al., J Immunol 2006, Sun et al., J Biol Chem 2008, Nishida et al., J Immunol 2011, Odai et al., J Biol Chem 1995, Anderson et al., J Biol Chem 1997, Hunter et al., Mol Endocrinol 1997, Feshchenko et al., J Biol Chem 1998, Park et al., J Immunol 1998, Gu et al., Mol Cell 1998
-
Reactome Reaction:
GRB2
→
PIK3R1
(direct_complex)
Onishi-Haraikawa et al., Biochem Biophys Res Commun 2001*
-
Reactome Reaction:
GRB2
→
PIK3R1
(indirect_complex)
Nishida et al., Blood 1999, Rodrigues et al., Mol Cell Biol 2000, Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Demiroglu et al., Blood 2001, Sattler et al., Cancer Cell 2002*, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Roumiantsev et al., Cancer Cell 2004, Jackson et al., Cancer Res 2004, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Yu et al., J Immunol 2006, Dufour et al., Bone 2008, Sun et al., J Biol Chem 2008, Carter et al., Proc Natl Acad Sci U S A 1991, Nishida et al., J Immunol 2011, Weng et al., J Biol Chem 1994, Odai et al., J Biol Chem 1995, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Anderson et al., J Biol Chem 1997, Harmer et al., Mol Cell Biol 1997, Hunter et al., Mol Endocrinol 1997, Fu et al., J Biol Chem 1997, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997, Bae et al., J Biol Chem 1998, Feshchenko et al., J Biol Chem 1998, Park et al., J Immunol 1998, Fu et al., Immunity 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
PIK3R1
—
GRB2
(coimmunoprecipitation)
Fukazawa et al., J Biol Chem 1996
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(physical association, affinity chromatography technology)
Gelkop et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(direct interaction, two hybrid)
Wang et al., J Biol Chem 1995*
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(direct interaction, pull down)
Saleem et al., J Biol Chem 1995*
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(physical association, affinity chromatography technology)
Wang et al., J Biol Chem 1995*
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(direct interaction, pull down)
Wang et al., J Biol Chem 1995*
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(direct interaction, two hybrid)
Bandyopadhyay et al., Nat Methods 2010
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(physical association, affinity chromatography technology)
Takahashi et al., J Cell Physiol 1999*
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(physical association, affinity chromatography technology)
Jain et al., Oncogene 1997*
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(physical association, affinity chromatography technology)
Ren et al., Exp Hematol 2005*
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(physical association, affinity chromatography technology)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(physical association, affinity chromatography technology)
Cerboni et al., Eur J Immunol 1998*
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(physical association, affinity chromatography technology)
Bisson et al., Nat Biotechnol 2011
-
IRef Biogrid Interaction:
PIK3R1
—
GRB2
(physical association, affinity chromatography technology)
Saleem et al., J Biol Chem 1995*
-
MIPS CORUM CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1):
CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) complex (BCAR1-CBL-CRK-GRB2-PIK3R1-SH3KBP1-SOS1)
Watanabe et al., Biochem Biophys Res Commun 2000
-
MIPS CORUM LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated:
LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated complex (CBL-GRB2-LAT-LCP2-PIK3R1-PLCG1-VAV1)
Zhang et al., Cell 1998
-
MIPS CORUM LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated:
LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated complex (GRB2-LAT-PIK3R1-PLCG1-SOS1)
Zhang et al., Cell 1998
-
IRef Corum Interaction:
Complex of LAT-PLCG1-PIK3R1-GRB2-SOS1
(association, coimmunoprecipitation)
Zhang et al., Cell 1998
-
IRef Corum Interaction:
Complex of LCP2-GRB2-PIK3R1-CBL-LAT-PLCG1-VAV1
(association, coimmunoprecipitation)
Zhang et al., Cell 1998
-
IRef Corum Interaction:
Complex of SH3KBP1-SOS1-PIK3R1-GRB2-CBL-BCAR1-CRK
(association, coimmunoprecipitation)
Watanabe et al., Biochem Biophys Res Commun 2000
-
IRef Hprd Interaction:
Complex of 50 proteins
(in vivo)
Watanabe et al., Biochem Biophys Res Commun 2000
-
IRef Hprd Interaction:
Complex of GRB2-CBL-PIK3R1-CBL-GRB2-PIK3R1-PIK3R1-GRB2-CBL
(in vivo)
Fukazawa et al., J Biol Chem 1995*
-
IRef Hprd Interaction:
PIK3R1
—
GRB2
(in vivo)
Ren et al., Exp Hematol 2005*, Kharbanda et al., J Biol Chem 1995*, Saleem et al., J Biol Chem 1995*, Wang et al., J Biol Chem 1995*, Panchamoorthy et al., J Biol Chem 1996
-
IRef Hprd Interaction:
PIK3R1
—
GRB2
(in vitro)
Ren et al., Exp Hematol 2005*, Kharbanda et al., J Biol Chem 1995*, Saleem et al., J Biol Chem 1995*, Wang et al., J Biol Chem 1995*, Panchamoorthy et al., J Biol Chem 1996
-
IRef Innatedb Interaction:
GRB2
—
PIK3R1
(unknown, -)
Saleem et al., J Biol Chem 1995*
-
IRef Intact Interaction:
Complex of UBASH3B-SHC1-PCCB-MCCC2-GRB2-INPPL1-CBL-PIK3R1-PIK3R2
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of 29 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 40 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 28 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of PIK3R1-EGFR-PTPN11-GAB2-GRB2
(association, anti tag coimmunoprecipitation)
Brummer et al., J Biol Chem 2006*
-
IRef Intact Interaction:
GRB2
—
PIK3R1
(physical association, pull down)
Ren et al., Exp Hematol 2005*
-
IRef Intact Interaction:
GRB2
—
PIK3R1
(physical association, two hybrid pooling approach)
Bandyopadhyay et al., Nat Methods 2010
-
IRef Intact Interaction:
GRB2
—
PIK3R1
(physical association, anti bait coimmunoprecipitation)
Fukazawa et al., J Biol Chem 1995*
-
IRef Intact Interaction:
Complex of 29 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of 37 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of 17 proteins
(association, anti bait coimmunoprecipitation)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Intact Interaction:
Complex of 12 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Ophid Interaction:
GRB2
—
PIK3R1
(aggregation, confirmational text mining)
Saleem et al., J Biol Chem 1995*
-
IRef Ophid Interaction:
GRB2
—
PIK3R1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Take et al., Biochem Biophys Res Commun 2000
:
Our results suggest that
CIN85 may
play a specific role in the
EGF receptor mediated signaling cascade via its interaction with c-Cbl
Wheeler et al., Mol Cell Biol 2001
:
Interaction with
Grb2 dramatically
increased the catalytic activity of this
PI3K
Petrelli et al., Nature 2002
:
Cbl, in turn, binds and ubiquitinates activated
HGF receptor , and by recruiting the
endophilin-CIN85 complex , it
regulates receptor internalization
Kowanetz et al., J Biol Chem 2003
:
Identification of a novel proline-arginine motif involved in
CIN85 dependent clustering of Cbl and down-regulation of
epidermal growth factor receptors
Choi et al., J Recept Signal Transduct Res 2004
:
PI3K inhibition
increased IRS-1-Grb2 complex formation and ras activity following insulin treatment of cells
Peruzzi et al., J Immunol 2007
(Calcium Signaling) :
We found that
CIN85 overexpression
inhibits the FcepsilonRI induced tyrosine phosphorylation of
phospholipase Cgamma , thus altering calcium mobilization ... Altogether, our findings support a new
role for
CIN85 in regulating
Syk protein levels in RBL-2H3 cells through the activation of the ubiquitin-proteasome pathway and provide a mechanism for this regulation involving c-Cbl ligase activity
Radhakrishnan et al., J Biol Chem 2008
(MAP Kinase Signaling System) :
Cellular exposure to 25 mm glucose, which is required for Shc phosphorylation in response to IGF-I, resulted in enhanced
Grb2 binding to p85,
activation of
PI3K activity, and increased AKT phosphorylation as compared with cells exposed to 5 mm glucose
Wakasaki et al., Neoplasia (New York, N.Y.) 2010
(Carcinoma, Squamous Cell...) :
Little is known, however, about a
role of
CIN85 in
EGFR signaling as well as its relevance to tumor development and progression of HNSCC
Marois et al., J Biol Chem 2011
:
Silencing the expression of
CIN85 by siRNA in dibutyryl cyclic AMP differentiated PLB 985 cells
prevented Fc?RIIa degradation and increased IgG mediated phagocytosis
Tossidou et al., Mol Cell Biol 2012
:
Our results indicate a novel
role for
CD2AP in regulating posttranslational modification of
CIN85
Samoylenko et al., Carcinogenesis 2012
(Adenocarcinoma...) :
Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of
Src , Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility ... Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src, Akt and
ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility ... Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src,
Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Schroeder et al., Mol Biol Cell 2012
:
In this study we show that
EGFR activation
leads to a pronounced src mediated tyrosine phosphorylation of
CIN85 that subsequently influences EGFR ubiquitination
Bior et al., FEBS Lett 2013
:
Dab1 stabilizes its interaction with
Cin85 by suppressing Cin85 phosphorylation at serine 587 ... Furthermore a
Cin85 Ser587 phosphomimetic
disrupts the
Dab1-Cin85 complex without affecting the Cin85-CapZ complex
Fuchigami et al., Genes Cells 2013
:
We reported previously that
Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation
regulates its binding to
CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases ... We reported previously that
Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation
regulates its binding to
CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases ... We reported previously that Cdk5-p35 phosphorylates
Dab1 at Ser400 and Ser491 and the phosphorylation
regulates its binding to
CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases
Kim et al., Endocrinology 1998
(Neuroblastoma) :
However, even though the
PI 3-K inhibitors
enhanced the association of
Grb2 with IRS-2, these compounds suppressed IGF-I induced mitogen activated protein kinase activation and neurite outgrowth