Gene interactions and pathways from curated databases and text-mining

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HBEGF — MMP1

Text-mined interactions from Literome

Shah et al., Mol Endocrinol 2004 : These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of MMP dependent HB-EGF release
Zhou et al., Am J Physiol Heart Circ Physiol 2007 : Inhibition of heparin binding EGF-like growth factor ( HB-EGF ) release by CRM-197 and inhibition of matrix metalloproteinases ( MMP ) by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation
Ancha et al., Int J Biochem Cell Biol 2007 (MAP Kinase Signaling System) : MMP-1 responses to histamine and HB-EGF were further tested by the use of H2 receptor antagonist, EGFR inhibitor and mitogen activator protein kinase ( MAPK ) inhibitor ... Histamine and HB-EGF caused a dose dependent release of MMP-1 with maximal responses that were 2.7- and 4.5-fold greater, respectively, than control, P < 0.001 ... MAPK inhibition also prevented histamine-and HB-EGF induced MMP-1 secretion
Ogunwobi et al., Br J Biomed Sci 2008 (Adenocarcinoma...) : Leptin increased extracellular release of HB-EGF and TGFalpha and this was blocked by matrix metalloproteinase ( MMP ) inhibitors