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AKT3 — HDAC1
Text-mined interactions from Literome
De Sarno et al., Neuropharmacology 2002
:
Two other inhibitors of
histone deacetylase , a recently identified target of sodium valproate, also
caused gradual increases in the phosphorylation of
Akt and GSK3beta
Chen et al., J Biol Chem 2005
:
Histone acetylation independent
effect of
histone deacetylase inhibitors on
Akt through the reshuffling of protein phosphatase 1 complexes
Lee et al., Mol Pharmacol 2008
:
Finally, activation of
Akt and CaM kinase II may eventually
lead to the acetylation of histone residues and phosphorylation of
histone deacetylase
Li et al., Cell Signal 2008
(Lymphoproliferative Disorders) :
Expression of
SAP in the A20 B cell line
led to a marked reduction in Blnk phosphorylation, a decrease in
Akt activation, and a near-complete ablation of phosphorylation of the MAP kinases Erk1/2, p38 and JNK upon colligation of FcgammaRIIB with the B cell receptor (BCR)
Lee et al., Proc Natl Acad Sci U S A 2012
:
The OSS induced
HDAC signaling and EC responses are
mediated by phosphatidylinositol
3-kinase/Akt
Moskowitz et al., Curr Oncol Rep 2012
(Hodgkin Disease) :
Additional agents that have demonstrated activity in HL include
histone deacetylase inhibitors, such as panobinostat, entinostat, and mocetinostat,
PI3-kinase/Akt/Mtor pathway
inhibitors , such as everolimus, as well as lenalidomide and bendamustine