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HDAC3 — TNF

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by HDAC Class I: TNF-alpha/TNFR1A complex (TNF-TNFRSF1A) → HDAC3/SMRT (N-CoR2) complex (HDAC3-NCOR2) (modification, activates)
  Gao et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events mediated by HDAC Class I: I kappa B alpha/HDAC3 complex (NFKBIA-HDAC3) → TNF-alpha/TNFR1A complex (TNF-TNFRSF1A) (modification, collaborate)
  
• NCI Pathway Database Signaling events mediated by HDAC Class I: TNF-alpha/TNFR1A complex (TNF-TNFRSF1A) → HDAC3 (HDAC3) (modification, activates)
• NCI Pathway Database Signaling events mediated by HDAC Class I: TNF-alpha/TNFR1A complex (TNF-TNFRSF1A) → HDAC3 (HDAC3) (translocation, activates)

Text-mined interactions from Literome

Mahlknecht et al., J Immunol 2004 : Histone deacetylase 3 , a class I histone deacetylase, suppresses MAPK11 mediated activating transcription factor-2 activation and represses TNF gene expression
Gao et al., J Biol Chem 2006 : Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator activated receptor gamma function ... In this study, we demonstrate that nuclear translocation of HDAC3 is regulated by TNF-alpha , and this event is required for inhibition of transcriptional activity of PPARgamma by TNF-alpha
Yan et al., Mol Endocrinol 2007 : An interaction of histone deacetylase 3 (HDAC3) and silencing mediator for retinoic acid receptor and thyroid hormone receptor ( SMRT ) with the PEPCK gene promoter was induced by TNF-alpha and observed in a chromatin immunoprecipitation assay