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HGF — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HGF(dimer)/MET(dimer)/GAB1 complex (MET-GAB1-HGF)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Yu et al., J Biol Chem 2001, Yu et al., J Biol Chem 2002*, Graziani et al., J Biol Chem 1991*, Schaeper et al., Proc Natl Acad Sci U S A 2007, Ponzetto et al., Cell 1994
Evidence: assay, physical interaction
Text-mined interactions from Literome
Dong et al., Cancer Res 2001
(Carcinoma, Squamous Cell...) :
Hepatocyte growth
factor/scatter factor induced activation of MEK and
PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
Li et al., Oncogene 2001
(Melanoma) :
All melanocytic cells expressed the HGF receptor c-Met, and autocrine
HGF caused constitutive activation of c-Met, MAPK and
PI3K
Recio et al., Oncogene 2002
(Melanoma) :
Activation of p38 kinase by
HGF/SF was partially blocked by the
PI3K-specific inhibitor as well
Yu et al., J Biol Chem 2002
:
These experiments demonstrate that EGF and
HGF mediated ERK activation result in divergent effects on
Gab1/PI3K signaling
Gahr et al., J Mol Endocrinol 2002
:
PI3'K activation was
necessary for
HGF- and glucose stimulated INS-1 cell proliferation
Taher et al., Biochem Biophys Res Commun 2002
(Arteriosclerosis...) :
Stimulation with
HGF led to activation of Met as well as to activation of
PI3-K , PKB/Akt, MEK, and the MAP kinases Erk1 and -2
Schulze-Bergkamen et al., Hepatology 2004
:
PI3K/Akt activation by
HGF results in the induction of antiapoptotic proteins such as Mcl-1
Halevy et al., Exp Cell Res 2004
(MAP Kinase Signaling System) :
UO126, a specific MAPK pathway inhibitor, had no effect on PI3K activity or Akt phosphorylation, implying that at least in muscle cells, the MAPK/ERK pathway is not required for
HGF induced
PI3K activation
Leibowitz-Amit et al., Cancer Res 2006
(Breast Neoplasms) :
In contrast, the level of phosphatidylinositol 3-kinase (PI3K) increases following Mimp induction and the level of phosphorylated
PI3K in
response to
HGF/SF is unaffected by the exogenous induction of Mimp
Oka et al., J Invest Dermatol 2008
(Melanoma...) :
Furthermore, the introduction of PKC-betaII suppressed
HGF induced activation of
PI3K , and attenuated the in vitro invasion activity of the melanoma cells
Singhal et al., J Biol Chem 2011
:
Notably, Btk activation is necessary for
HGF induced association of c-Src and
PI3K with c-MET
Chen et al., PloS one 2012
:
Hepatocyte growth factor increases osteopontin expression in human osteoblasts through
PI3K , Akt, c-Src, and AP-1 signaling pathway ... Stimulation of osteoblasts with
HGF enhanced
PI3K , Akt, and c-Src activation
Meyer et al., Frontiers in physiology 2012
:
Among others
PI3K signaling is
activated by the
hepatocyte growth factor (HGF) that regulates proliferation of hepatocytes during liver regeneration but also fosters tumor cell proliferation
Martínez-Palacián et al., PloS one 2013
:
Altogether, results presented here provide solid evidences that both paracrine and autocrine
HGF/Met signaling
requires PI3K to promote mouse hepatic oval cell survival against TGF-ß induced oxidative stress and apoptosis
Johnson et al., Biochem Mol Biol Int 1995
(Second Messenger Systems) :
In both M23 and MM55 cells,
HGF induces association with MET/HGFR and
increased tyrosine phosphorylation of the SH2-domain containing proteins
PI3K , GAP and NCK