Gene interactions and pathways from curated databases and text-mining

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HGF — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Dong et al., Cancer Res 2001 (Carcinoma, Squamous Cell...) : Hepatocyte growth factor/scatter factor induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
Li et al., Oncogene 2001 (Melanoma) : All melanocytic cells expressed the HGF receptor c-Met, and autocrine HGF caused constitutive activation of c-Met, MAPK and PI3K
Recio et al., Oncogene 2002 (Melanoma) : Activation of p38 kinase by HGF/SF was partially blocked by the PI3K-specific inhibitor as well
Yu et al., J Biol Chem 2002 : These experiments demonstrate that EGF and HGF mediated ERK activation result in divergent effects on Gab1/PI3K signaling
Gahr et al., J Mol Endocrinol 2002 : PI3'K activation was necessary for HGF- and glucose stimulated INS-1 cell proliferation
Taher et al., Biochem Biophys Res Commun 2002 (Arteriosclerosis...) : Stimulation with HGF led to activation of Met as well as to activation of PI3-K , PKB/Akt, MEK, and the MAP kinases Erk1 and -2
Schulze-Bergkamen et al., Hepatology 2004 : PI3K/Akt activation by HGF results in the induction of antiapoptotic proteins such as Mcl-1
Halevy et al., Exp Cell Res 2004 (MAP Kinase Signaling System) : UO126, a specific MAPK pathway inhibitor, had no effect on PI3K activity or Akt phosphorylation, implying that at least in muscle cells, the MAPK/ERK pathway is not required for HGF induced PI3K activation
Leibowitz-Amit et al., Cancer Res 2006 (Breast Neoplasms) : In contrast, the level of phosphatidylinositol 3-kinase (PI3K) increases following Mimp induction and the level of phosphorylated PI3K in response to HGF/SF is unaffected by the exogenous induction of Mimp
Oka et al., J Invest Dermatol 2008 (Melanoma...) : Furthermore, the introduction of PKC-betaII suppressed HGF induced activation of PI3K , and attenuated the in vitro invasion activity of the melanoma cells
Singhal et al., J Biol Chem 2011 : Notably, Btk activation is necessary for HGF induced association of c-Src and PI3K with c-MET
Chen et al., PloS one 2012 : Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K , Akt, c-Src, and AP-1 signaling pathway ... Stimulation of osteoblasts with HGF enhanced PI3K , Akt, and c-Src activation
Meyer et al., Frontiers in physiology 2012 : Among others PI3K signaling is activated by the hepatocyte growth factor (HGF) that regulates proliferation of hepatocytes during liver regeneration but also fosters tumor cell proliferation
Martínez-Palacián et al., PloS one 2013 : Altogether, results presented here provide solid evidences that both paracrine and autocrine HGF/Met signaling requires PI3K to promote mouse hepatic oval cell survival against TGF-ß induced oxidative stress and apoptosis
Johnson et al., Biochem Mol Biol Int 1995 (Second Messenger Systems) : In both M23 and MM55 cells, HGF induces association with MET/HGFR and increased tyrosine phosphorylation of the SH2-domain containing proteins PI3K , GAP and NCK