Royal et al., Mol Biol Cell 2000
:
HGF induces activation of the Cdc42/Rac regulated p21 activated kinase (PAK) and c-Jun N-terminal kinase, and translocation of Rac, PAK, and Rho dependent Rho-kinase to membrane ruffles
Hakuma et al., Cancer Res 2005
(Carcinoma, Non-Small-Cell Lung...) :
LCD-E1AF cells had more GTP bound ( active ) Rho than LCD-vector cells and Rho activation was synergistically increased by HGF ... The Rho activation by E1AF and HGF was also shown in NCI-H226 cells
McClelland et al., Pigment Cell Melanoma Res 2011
(Melanoma...) :
We also show that Rho activity is significantly reduced in cells expressing Plexin B1, and that Plexin B1 suppresses HGF dependent Rho activation