Gene interactions and pathways from curated databases and text-mining

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HIF1A — LPA

Text-mined interactions from Literome

Lee et al., Clin Cancer Res 2006 (Neoplasm Invasiveness...) : LPA induced expressions of VEGF and HIF-1alpha in OVCAR-3, CAOV-3, PC-3, and SK-Hep1 cells but not in SKOV-3 and Hep-3B cells ... In OVCAR-3 and PC-3 cells, the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin/p70S6K and p42/p44 mitogen activated protein kinase pathways were required for LPA induced HIF-1alpha and VEGF expressions, whereas only the phosphoinositide 3-kinase/mammalian target of rapamycin/p70S6K pathway was important in SK-Hep1 cells
Park et al., Cancer Lett 2007 (Ovarian Neoplasms) : Hypoxia enhances LPA induced HIF-1alpha and VEGF expression : their inhibition by resveratrol ... In the present study, we investigated the effects of LPA and hypoxia on HIF-1alpha and VEGF expression, as well as the effect of resveratrol on LPA and hypoxia induced HIF-1alpha and VEGF expression and human ovarian cancer cell migration