◀ Back to PIK3R1
HIF1A — PIK3R1
Text-mined interactions from Literome
Zhong et al., Cancer Res 2000
(Anoxia...) :
Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen induced expression of
hypoxia-inducible factor 1 (HIF-1) alpha , the regulated subunit of the transcription factor HIF-1, is
blocked by LY294002 and rapamycin, inhibitors of
PI3K and FRAP, respectively
Hwang et al., Carcinogenesis 2004
(Prostatic Neoplasms) :
Phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin signaling was also
involved in vanadate induced
HIF-1alpha expression, but it was independent of AMPK signaling pathway
Schnitzer et al., FEBS Lett 2005
:
We investigated how
PI3K/Akt and glycogen synthase kinase 3beta ( GSK3beta )
affect HIF-1alpha in human RKO cells under prolonged periods of severe hypoxia/anoxia
Hellwig-Bürgel et al., Cell Physiol Biochem 2005
:
The study shows that
PI3K but not MAPKK-1 inhibition
resulted in the loss of hypoxic and IL-1beta induced
HIF-1alpha accumulation, whereas VEGF synthesis was reduced by either intervention ... Thus,
PI3K signaling is
required for
HIF-1alpha accumulation and VEGF synthesis, whereas MAPKK-1 signaling is required for VEGF synthesis only
Dimova et al., Thromb Haemost 2005
(MAP Kinase Signaling System...) :
Inhibition of either the
PI3K by LY294002 or ERK1/2 by U0126
reduced HIF-1alpha protein levels while both inhibitors together completely abolished the IGF-1 effect on
HIF-1alpha
Li et al., Int J Mol Med 2006
:
Further, we found that
PI3K inhibitors, LY294002 and Wortmannin,
inhibited HIF-1alpha and VEGF expression induced by UV radiation
Tanaka et al., Cancer Res 2006
(Anoxia...) :
On the other hand, Akt, the pathway of which can up-regulate HIF-1alpha expression, was activated in the mouse lesions, whereas HIF-1alpha was markedly down-regulated in the mouse hepatocellular carcinoma ( HCC ) cell lines after treatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that
HIF-1alpha expression is
dependent on
PI3K/Akt signaling
Tomita et al., Biochem J 2007
(Leukemia, T-Cell) :
The
PI3K inhibitor LY294002
suppressed HIF-1alpha protein expression, HIF-1 DNA binding and HIF-1 transcriptional activity in HTLV-1 infected T-cell lines
Westra et al., Ann N Y Acad Sci 2007
(Arthritis, Rheumatoid) :
The
effect of inhibitors of the
PI3K and the ERK pathway on
HIF-1alpha protein expression was measured ... Furthermore, it was shown that cytokine induced mRNA expression of
HIF-1alpha was
inhibited by the
PI3K inhibitor
Park et al., J Cell Biochem 2008
:
But our study revealed, through p53 mutant-type as well as p53 null cell lines, that neither the
PI3K/Akt nor the p53 signaling pathway is
required for quercetin induced
HIF-1alpha accumulation
Wunderlich et al., Exp Dermatol 2008
:
Our findings indicate the
involvement of
PI3K in UVB mediated
HIF-1alpha upregulation
Li et al., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2008
(Hypoxia-Ischemia, Brain) :
To investigate the expression of hypoxia inducible factor 1alpha ( HIF-1alpha ) protein and the activation of phosphoinositide 3-kinase/Akt (PI3K/Akt) signaling pathway in neurons under hypoxia ischemia condition, and to elucidate the
role of
PI3K/Akt on
HIF-1alpha regulation in the developing neurons after hypoxia ischemia brain damage ( HIBD )
Yang et al., Invest Ophthalmol Vis Sci 2009
(Anoxia...) :
Role of
PI3K/Akt and MEK/ERK in mediating hypoxia induced expression of
HIF-1alpha and VEGF in laser induced rat choroidal neovascularization ... A well established rat model of CNV and cultured human retinal pigment epithelium ( hRPE ) was used to investigate the
role of
PI3K/Akt and MEK/ERK pathways in regulating
HIF-1alpha and VEGF expression in CNV in rat and hRPE under hypoxia by immunohistochemistry, Western blot analysis, real-time PCR, and ELISA
Petrella et al., Cancer Biol Ther 2009
(Carcinoma, Renal Cell...) :
Activation of
PI3K/Akt/mTOR leads to increased
HIF-1alpha expression in certain cancer cells, supporting the rationale of using mTOR inhibitors as anti-cancer agents
Koshikawa et al., J Biol Chem 2009
(Carcinoma, Lewis Lung) :
Stimulation of
HIF-1alpha transcription by the ND6 mutation was
mediated by overproduction of reactive oxygen species ( ROS ) and subsequent activation of phosphatidylinositol 3-kinase
(PI3K)-Akt and protein kinase C ( PKC ) signaling pathways
Westra et al., BMC musculoskeletal disorders 2010
(Arthritis...) :
HIF-1 alpha protein expression in LPS stimulated THP-1 macrophages could be
blocked by ERK- and
PI3K-inhibitors , but also by the CaMKII inhibitor KN93