Gene interactions and pathways from curated databases and text-mining

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HIF1A — PIK3R1

Text-mined interactions from Literome

Zhong et al., Cancer Res 2000 (Anoxia...) : Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen induced expression of hypoxia-inducible factor 1 (HIF-1) alpha , the regulated subunit of the transcription factor HIF-1, is blocked by LY294002 and rapamycin, inhibitors of PI3K and FRAP, respectively
Hwang et al., Carcinogenesis 2004 (Prostatic Neoplasms) : Phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin signaling was also involved in vanadate induced HIF-1alpha expression, but it was independent of AMPK signaling pathway
Schnitzer et al., FEBS Lett 2005 : We investigated how PI3K/Akt and glycogen synthase kinase 3beta ( GSK3beta ) affect HIF-1alpha in human RKO cells under prolonged periods of severe hypoxia/anoxia
Hellwig-Bürgel et al., Cell Physiol Biochem 2005 : The study shows that PI3K but not MAPKK-1 inhibition resulted in the loss of hypoxic and IL-1beta induced HIF-1alpha accumulation, whereas VEGF synthesis was reduced by either intervention ... Thus, PI3K signaling is required for HIF-1alpha accumulation and VEGF synthesis, whereas MAPKK-1 signaling is required for VEGF synthesis only
Dimova et al., Thromb Haemost 2005 (MAP Kinase Signaling System...) : Inhibition of either the PI3K by LY294002 or ERK1/2 by U0126 reduced HIF-1alpha protein levels while both inhibitors together completely abolished the IGF-1 effect on HIF-1alpha
Li et al., Int J Mol Med 2006 : Further, we found that PI3K inhibitors, LY294002 and Wortmannin, inhibited HIF-1alpha and VEGF expression induced by UV radiation
Tanaka et al., Cancer Res 2006 (Anoxia...) : On the other hand, Akt, the pathway of which can up-regulate HIF-1alpha expression, was activated in the mouse lesions, whereas HIF-1alpha was markedly down-regulated in the mouse hepatocellular carcinoma ( HCC ) cell lines after treatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha expression is dependent on PI3K/Akt signaling
Tomita et al., Biochem J 2007 (Leukemia, T-Cell) : The PI3K inhibitor LY294002 suppressed HIF-1alpha protein expression, HIF-1 DNA binding and HIF-1 transcriptional activity in HTLV-1 infected T-cell lines
Westra et al., Ann N Y Acad Sci 2007 (Arthritis, Rheumatoid) : The effect of inhibitors of the PI3K and the ERK pathway on HIF-1alpha protein expression was measured ... Furthermore, it was shown that cytokine induced mRNA expression of HIF-1alpha was inhibited by the PI3K inhibitor
Park et al., J Cell Biochem 2008 : But our study revealed, through p53 mutant-type as well as p53 null cell lines, that neither the PI3K/Akt nor the p53 signaling pathway is required for quercetin induced HIF-1alpha accumulation
Wunderlich et al., Exp Dermatol 2008 : Our findings indicate the involvement of PI3K in UVB mediated HIF-1alpha upregulation
Li et al., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2008 (Hypoxia-Ischemia, Brain) : To investigate the expression of hypoxia inducible factor 1alpha ( HIF-1alpha ) protein and the activation of phosphoinositide 3-kinase/Akt (PI3K/Akt) signaling pathway in neurons under hypoxia ischemia condition, and to elucidate the role of PI3K/Akt on HIF-1alpha regulation in the developing neurons after hypoxia ischemia brain damage ( HIBD )
Yang et al., Invest Ophthalmol Vis Sci 2009 (Anoxia...) : Role of PI3K/Akt and MEK/ERK in mediating hypoxia induced expression of HIF-1alpha and VEGF in laser induced rat choroidal neovascularization ... A well established rat model of CNV and cultured human retinal pigment epithelium ( hRPE ) was used to investigate the role of PI3K/Akt and MEK/ERK pathways in regulating HIF-1alpha and VEGF expression in CNV in rat and hRPE under hypoxia by immunohistochemistry, Western blot analysis, real-time PCR, and ELISA
Petrella et al., Cancer Biol Ther 2009 (Carcinoma, Renal Cell...) : Activation of PI3K/Akt/mTOR leads to increased HIF-1alpha expression in certain cancer cells, supporting the rationale of using mTOR inhibitors as anti-cancer agents
Koshikawa et al., J Biol Chem 2009 (Carcinoma, Lewis Lung) : Stimulation of HIF-1alpha transcription by the ND6 mutation was mediated by overproduction of reactive oxygen species ( ROS ) and subsequent activation of phosphatidylinositol 3-kinase (PI3K)-Akt and protein kinase C ( PKC ) signaling pathways
Westra et al., BMC musculoskeletal disorders 2010 (Arthritis...) : HIF-1 alpha protein expression in LPS stimulated THP-1 macrophages could be blocked by ERK- and PI3K-inhibitors , but also by the CaMKII inhibitor KN93