Gene interactions and pathways from curated databases and text-mining

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CD4 — HLA-DRB1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Bartnes et al., Immunology 2000 (Lymphoma, B-Cell...) : Immunoglobulin peptide/MHC class II complexes may also be involved in autoimmunity and CD4+ T-cell mediated B-cell regulation
Zhou et al., Cell Signal 2003 (Calcium Signaling) : T cell receptor independent CD4 signalling : CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP
Carbonneil et al., Int Immunol 2004 : In addition, neutralization of IL-10 during the differentiation of DCs increased the expression of DC-LAMP and MHC class II by IFN-DCs, and the ability of IFN-DCs to stimulate allogeneic CD4 ( + ) T-cell proliferation at similar levels, than IL-4-DCs
Herbeuval et al., Blood 2005 (HIV Infections) : The present study investigates the expression of TRAIL death receptor 5 (DR5) in the peripheral-blood mononuclear cells ( PBMCs ) of HIV-1 infected patients and its role in CD4 ( + ) T-cell death ... Induction of apoptosis and DR5 expression required glycoprotein 120 (gp120)-CD4 interaction
Herbeuval et al., AIDS Rev 2006 (HIV Infections) : However, soluble CD4 ( sCD4-IgG ) efficiently blocked IFNalpha production, TRAIL and DR5 expression and apoptosis of T helper cells
Chakraverty et al., Blood 2006 : CD8 ( + ) T-cell dependent GVL responses against an MHC class II-negative tumor following delayed DLI require CD4 ( + ) T-cell help and are reduced significantly when host APCs lack MHC class II expression
Herbeuval et al., Clin Immunol 2007 (HIV Infections) : The binding of infectious or noninfectious HIV-1 to CD4 on these T cells results in expression of the TRAIL death receptor 5 (DR5) , leading to the selective death of HIV exposed CD4+ T cells
Dao et al., PloS one 2009 : However, only DR-1 stimulated CD4 or CD3 T cells possessed cytotoxicity against peptide pulsed autologous DCs and a cancer cell line, that expresses a high level of cyclin D1
Dong et al., PloS one 2013 : The dendritic cell-driven Qa2 induction of CD4 ( + ) pre-RTEs is independent of MHC class II and Aire molecules