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HMGB1 — IL8

Text-mined interactions from Literome

Taniguchi et al., Arthritis Rheum 2003 (Arthritis, Rheumatoid...) : SFMs expressed RAGE and released TNFalpha, interleukin-1beta (IL-1beta), and IL-6 upon stimulation with HMGB-1
Yu et al., Shock 2006 : Here we demonstrate that in human whole blood, neutralizing antibodies against Toll-like receptor 4 ( TLR4, but not TLR2 or receptor for advanced glycation end product ) dose-dependently attenuate HMGB1 induced IL-8 release ... However, in human embryonic kidney 293 cells transfected with TLR2 or TLR4, HMGB1 effectively induces IL-8 release only from TLR2 overexpressing cells ... However, in human embryonic kidney 293 cells transfected with TLR2 or TLR4, HMGB1 effectively induces IL-8 release only from TLR2 overexpressing cells ... Consistently, anti-TLR2 antibodies dose-dependently attenuate HMGB1 induced IL-8 release in human embryonic kidney/TLR2 expressing cells and markedly reduce HMGB1 cell surface binding on murine macrophage-like RAW 264.7 cells
Song et al., Clin Exp Immunol 2008 : Only supernatants from hypothermia susceptible cells up-regulated the expression of interleukin (IL)-8 and adhesion molecules in cultured endothelial cells in an HMGB1 dependent manner
Kamau et al., J Gen Virol 2009 : HMGB1 regulated tumour necrosis factor alpha, interleukin (IL)-6 , IL-8 and alpha interferon secretion in DENV infected DCs
Crouser et al., Crit Care Med 2009 (Necrosis) : Likewise, high mobility group box 1 , the nuclear homolog of TFAM, did not induce monocyte IL-8 release unless combined with mitochondrial N-formyl peptides
Zhong et al., Nan Fang Yi Ke Da Xue Xue Bao 2009 : Stimulation of the HUVECs with LPS ( 10 ng < ml ) or HMGB1 ( 15 ng/ml ) alone resulted in significantly increased levels of IL-8 and MCP-1 ( P < 0.01 ), which were further increased after costimulation with LPS and HMGB1, suggesting a synergistic effect between HMGB1 and LPS ( P < 0.01 )
García-Arnandis et al., Arthritis Res Ther 2010 (MAP Kinase Signaling System...) : In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6, IL-8 , CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß, a significant potentiation of protein and mRNA expression, as well as MMP activity was observed ... In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6, IL-8 , CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß, a significant potentiation of protein and mRNA expression, as well as MMP activity was observed
Lynch et al., Am J Nephrol 2010 : HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has putative intracellular signalling effects regulating the production of interleukin-1 and tumour necrosis factor in a number of inflammatory conditions
Wähämaa et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid...) : Stimulation with HMGB1 in complex with LPS, IL-1a or IL-1ß enhanced production of TNF, IL-6 and IL-8
Carbone et al., Clin Cancer Res 2012 (Cell Transformation, Neoplastic...) : HMGB1 and Nalp3 induce proinflammatory responses and lead to interleukin-1ß and TNF-a secretion and NF-?B activity, thereby promoting cell survival and tumor growth
Weng et al., Shock 2012 (Acute Disease...) : Honokiol significantly reduced the increases in serum tumor necrosis factor-a, interleukin 1, and nitric oxide levels 3 h and serum high-mobility group box 1 24 h after acute pancreatitis induction