Gene interactions and pathways from curated databases and text-mining

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HMGB1 — PIK3R1

Text-mined interactions from Literome

Oh et al., Int Immunopharmacol 2011 : CKD712, ( S ) -1- ( a-naphthylmethyl ) -6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C
Yang et al., Mol Biol Rep 2012 (Coronary Restenosis...) : We also found pretreated cells with TLR4 siRNA or the PI3 K inhibitor LY294002 could markedly block PI3K/Akt pathway activation and VSMCs migration mediated by HMGB1 ( P both < 0.05 )