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HMOX1 — VCAM1
Text-mined interactions from Literome
Soares et al., J Immunol 2004
(MAP Kinase Signaling System) :
We found that
HO-1 overexpression in EC
inhibited TNF-alpha mediated E-selectin and
VCAM-1 , but not ICAM-1 expression, as tested at the RNA and protein level
Pae et al., Atherosclerosis 2006
(Atherosclerosis) :
Based on our findings, we suggest that Nrf2 dependent
HO-1 expression induced by HA
inhibits MCP-1 secretion,
VCAM-1 expression and NF-kappaB activation associated with vascular injury and inflammation in atherosclerosis
Belcher et al., J Clin Invest 2006
(Anemia, Sickle Cell...) :
Treatment of sickle mice with hemin further increases
heme oxygenase-1 expression and
inhibits hypoxia/reoxygenation induced stasis, leukocyte-endothelium interactions, and NF-kappaB,
VCAM-1 , and ICAM-1 expression
Hurttila et al., Gene Ther 2008
(Cardiovascular Diseases) :
In human endothelial cells, ARE-driven
HO-1 overexpression
inhibited nuclear factor-kappaB activation and subsequent
vascular cell adhesion molecule-1 expression induced by tumor necrosis factor-alpha
Lee et al., Am J Pathol 2009
(Tracheitis) :
In addition,
HO-1 overexpression
inhibited TNF-alpha induced intercellular adhesion molecule-1 and
vascular cell adhesion molecule-1 expression, adherence of THP-1 cells, generation of interleukin-6, p47(phox) translocation, and nuclear factor-kappaB activation