Gene interactions and pathways from curated databases and text-mining

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HMOX1 — VCAM1

Text-mined interactions from Literome

Soares et al., J Immunol 2004 (MAP Kinase Signaling System) : We found that HO-1 overexpression in EC inhibited TNF-alpha mediated E-selectin and VCAM-1 , but not ICAM-1 expression, as tested at the RNA and protein level
Pae et al., Atherosclerosis 2006 (Atherosclerosis) : Based on our findings, we suggest that Nrf2 dependent HO-1 expression induced by HA inhibits MCP-1 secretion, VCAM-1 expression and NF-kappaB activation associated with vascular injury and inflammation in atherosclerosis
Belcher et al., J Clin Invest 2006 (Anemia, Sickle Cell...) : Treatment of sickle mice with hemin further increases heme oxygenase-1 expression and inhibits hypoxia/reoxygenation induced stasis, leukocyte-endothelium interactions, and NF-kappaB, VCAM-1 , and ICAM-1 expression
Hurttila et al., Gene Ther 2008 (Cardiovascular Diseases) : In human endothelial cells, ARE-driven HO-1 overexpression inhibited nuclear factor-kappaB activation and subsequent vascular cell adhesion molecule-1 expression induced by tumor necrosis factor-alpha
Lee et al., Am J Pathol 2009 (Tracheitis) : In addition, HO-1 overexpression inhibited TNF-alpha induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression, adherence of THP-1 cells, generation of interleukin-6, p47(phox) translocation, and nuclear factor-kappaB activation