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ALB — HNF1A
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
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HNF1A
(directlyIncreases, ALB Activity)
Evidence: Studies of the DBP gene proximal promoter have identified three functional hepatocyte nuclear factor 1 (HNF1)-binding sites within 2 kb of the transcriptional start site. The activities of the two more distal HNF1-binding sites were found to be dependent upon the relative levels of the two isoforms of this transcription factor, HNF1a and HNF1b. This was because HNF1b acted as a trans-dominant inhibitor of HNF1amediated enhancer activity14. The relative levels of these HNF1 isoforms in liver and ...
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Dohda et al., J Biochem 2004
:
Transcriptional coactivators CBP and p300 cooperatively enhance
HNF-1alpha mediated expression of the
albumin gene in hepatocytes ... Luciferase reporter assays showed that CBP and p300 cooperatively triggered
HNF-1alpha mediated transcription of the
albumin promoter
Kurosawa et al., Tissue Eng 2005
:
The expression of HNF-4 and HNF-1alpha, which are liver enriched transcription factors, did not differ between the monolayer and cocultured Fao cells, suggesting that expression of HNF-4 and
HNF-1alpha was not
responsible for the increased expression
albumin and apoA-I
Prajapati et al., Neurol Res 2012
(Brain Ischemia...) :
Hepatocyte nuclear factor-1alpha mediated upregulation of
albumin expression in focal ischemic rat brain ... Although,
HNF-1alpha is mainly expressed in the rat liver and
involved in hepatic expression of
albumin , our study conclusively shows for the first time de novo synthesis of HNF-1alpha in rat brain