Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

HRG — PIK3R1

Text-mined interactions from Literome

Tan et al., Cancer Res 1999 (Breast Neoplasms) : HRG-beta also increased the kinase activities of extracellular signal regulated protein kinase ( ERK ) and PI3K in these cells
Ram et al., J Cell Physiol 2000 (Breast Neoplasms) : Finally, HRG-beta was also an especially potent inducer of PI3K in the nontransformed MCF-10A cells, which were derived spontaneously from normal reduction mammoplasty tissue
Sun et al., J Cell Physiol 2002 (Breast Neoplasms) : The activation of both ERK and PI3-K was essential for HRG regulation of COXII, i.e., blockage of either pathway eliminated HRG mediated alteration
Hamburger et al., Anticancer Res 1997 : The purpose of these experiments was to determine the effects of heregulin beta 1 (HRG) on growth and PI3K activation of a nonneoplastic human mammary epithelial cell line, 184B5 ... Similarly, HRG at all concentrations stimulated the association of PI3K with erbB3 ... We conclude that both the growth inhibitory and stimulatory effects of HRG in nonneoplastic human mammary epithelial cells are mediated by activation of PI3K