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HRG — PIK3R1
Text-mined interactions from Literome
Tan et al., Cancer Res 1999
(Breast Neoplasms) :
HRG-beta also
increased the kinase activities of extracellular signal regulated protein kinase ( ERK ) and
PI3K in these cells
Ram et al., J Cell Physiol 2000
(Breast Neoplasms) :
Finally,
HRG-beta was also an especially potent
inducer of
PI3K in the nontransformed MCF-10A cells, which were derived spontaneously from normal reduction mammoplasty tissue
Sun et al., J Cell Physiol 2002
(Breast Neoplasms) :
The activation of both ERK and
PI3-K was
essential for
HRG regulation of COXII, i.e., blockage of either pathway eliminated HRG mediated alteration
Hamburger et al., Anticancer Res 1997
:
The purpose of these experiments was to determine the
effects of
heregulin beta 1 (HRG) on growth and
PI3K activation of a nonneoplastic human mammary epithelial cell line, 184B5 ... Similarly,
HRG at all concentrations
stimulated the association of
PI3K with erbB3 ... We conclude that both the growth inhibitory and stimulatory effects of
HRG in nonneoplastic human mammary epithelial cells are
mediated by activation of
PI3K