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HSD11B2 — MAPK6

Text-mined interactions from Literome

Ignatova et al., Am J Physiol Endocrinol Metab 2009 (Carcinoma, Hepatocellular...) : To our knowledge, this is the first study showing involvement of p38 MAPK in the TNF-alpha mediated 11beta-HSD1 regulation, and that TNF-alpha stimulates enzyme activity in vivo
Sharma et al., Endocrinology 2009 : We showed that inhibition of p38 MAPK with the pharmacological inhibitor SB202190 led to an approximately 50 % reduction in 11beta-HSD2 activity, protein, and mRNA in primary human placental trophoblast cells ... In addition, SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity, indicating that p38 MAPK regulates placental 11beta-HSD2 expression through modulation of 11beta-HSD2 mRNA stability