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BCL2 — HSP90AA1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BCL2 — HSP90AA1 (physical association, affinity chromatography technology) Trisciuoglio et al., PloS one 2010*
• IRef Biogrid Interaction: BCL2 — HSP90AA1 (physical association, affinity chromatography technology) Xu et al., FASEB J 2011*

Text-mined interactions from Literome

Dias et al., Blood 2002 (Leukemia...) : VEGF ( 165 ) promotes survival of leukemic cells by Hsp90 mediated induction of Bcl-2 expression and apoptosis inhibition
Kuo et al., J Immunol 2007 : Inhibition of Hsp90beta suppressed the CpG-B ODN induced association of Hsp90beta with Bcl-2 and impaired the inhibitory effect of CpG-B ODN in the release of cytochrome c and activation of caspase-3
Bansal et al., Blood 2010 (Leukemia, Myeloid) : Furthermore, Hsp90 inhibitors 17-AAG [ 17- ( allylamino ) -17-demethoxygeldanamycin ] and STA-9090 significantly reduced the growth of myeloid leukemia xenografts in vivo and effectively down-regulated the expression of WT1 and its downstream target proteins, c-Myc and Bcl-2
Bansal et al., J Biol Chem 2012 (Leukemia, Myeloid, Acute) : Consistent with this, pharmacological inhibition of Hsp90 resulted in reduced WT1 and Bcl-xL expression leading to increased sensitivity of leukemia cells to TRAIL mediated apoptosis