Gene interactions and pathways from curated databases and text-mining

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HSP90AA1 — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Fujita et al., J Biol Chem 2002 : Hsp90 inhibitors had no effect on PI3K protein expression
Redlak et al., Dig Dis Sci 2011 (Stomach Neoplasms) : The binding of HSP90 with pro-survival kinase Akt prevents proteosomal degradation of Akt and contributes to the functional stabilization of PI3K/Akt signaling and cell survival
Wang et al., PloS one 2011 (Adenocarcinoma...) : Several compounds in the categories of HSP90 inhibitor, HDAC inhibitor, PPAR agonist, PI3K inhibitor , passed our screening to be the leading candidates
Tramentozzi et al., J Cell Mol Med 2011 : Results reveal a fundamental role of HSP90 in the PI3K/Akt pathway mediated angiogenic-like effect of Grp94-IgG, also questioning the capacity of CTT to serve as an effective inhibitor of the angiogenic effect