◀ Back to PIK3R1
HSP90AA1 — PIK3R1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
HSP90AA1
→
PIK3R1
(reaction)
Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007
-
Reactome Reaction:
HSP90AA1
→
PIK3R1
(indirect_complex)
Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fujita et al., J Biol Chem 2002
:
Hsp90 inhibitors
had no effect on
PI3K protein expression
Redlak et al., Dig Dis Sci 2011
(Stomach Neoplasms) :
The binding of
HSP90 with pro-survival kinase Akt prevents proteosomal degradation of Akt and
contributes to the functional stabilization of
PI3K/Akt signaling and cell survival
Wang et al., PloS one 2011
(Adenocarcinoma...) :
Several compounds in the categories of
HSP90 inhibitor, HDAC inhibitor, PPAR agonist,
PI3K inhibitor , passed our screening to be the leading candidates
Tramentozzi et al., J Cell Mol Med 2011
:
Results reveal a fundamental
role of
HSP90 in the
PI3K/Akt pathway mediated angiogenic-like effect of Grp94-IgG, also questioning the capacity of CTT to serve as an effective inhibitor of the angiogenic effect