Gene interactions and pathways from curated databases and text-mining

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HSPB1 — MAPK6

Text-mined interactions from Literome

Hedges et al., J Biol Chem 1999 : Activation of p38 ( MAPK ) resulted in the phosphorylation of HSP27 ( heat shock protein 27 ), which may modulate F-actin polymerization ... Inhibition of p38 ( MAPK ) activity inhibited phosphorylation of HSP27
Leal et al., Toxicol Appl Pharmacol 2002 : Lead stimulated p38MAPK dependent Hsp27 phosphorylation
Mizutani et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System...) : The p38 MAPK inhibitor, SB203580, inhibited effectively phosphorylation of HSP-27 , CREB, and eIF4E in SARS-CoV infected cells
Marais et al., Basic Res Cardiol 2005 : The results suggest that p38 MAPK activation triggers HSP27 phosphorylation during both the preconditioning protocols and during sustained ischaemia
Berkowitz et al., J Biol Chem 2005 (Pemphigus) : Inhibition of p38MAPK activity prevented PV IgG induced HSP27 phosphorylation, keratin filament retraction, and actin reorganization
Buitrago et al., J Cell Biochem 2006 : Of relevance, 1alpha,25 ( OH ) 2D3 induced in the C2C12 line the stimulation of mitogen activated protein kinase activating protein kinase 2 ( MAPKAP-kinase 2 ) and subsequent phosphorylation of heat shock protein 27 (HSP27) in a p38 kinase activation dependent manner
Rafiee et al., Am J Physiol Cell Physiol 2006 : The p38 MAPK inhibitor ( SB-203580 ) and p38 MAPK siRNA blocked Hsp27 and Hsp70 mRNA induction, suggesting a role for MAPKs in the HEMEC heat shock response
Shi et al., Breast Cancer Res Treat 2006 (Breast Neoplasms) : Inhibition of p38 MAPK resulted in decreased phospho-HSP-27 and phospho-Akt, while down-regulation of HSP-27 with a small interfering RNA decreased phosphorylation of Akt, directly linking activation of p38 to Akt
Yuan et al., J Cell Biochem 2008 (Carcinoma, Pancreatic Ductal...) : PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells ... Thus, neurotensin induces Hsp27 Ser-82 phosphorylation through p38 MAPK- and PKC/PKD dependent pathways in PANC-1 cells
Nomura et al., Biochem Pharmacol 2007 (Glioblastoma) : SB203580 or p38MAPK siRNA blocked these phenomena, indicating that Hsp27 phosphorylation and translocation from cytosol to membrane were mediated by p38MAPK
Li et al., Am J Physiol Heart Circ Physiol 2008 (Disease Models, Animal...) : Inhibition of p38 MAPK with SB-203580 blocked the insulin induced phosphorylation of Hsp27 and the improved functional recovery
Srinivasan et al., Am J Physiol Heart Circ Physiol 2008 : The parallel activation of Hsp27 by NE was p38 MAPK dependent and led to its dissociation from actin filaments and translocation from membrane to cytosol and increased actin polymerization ... Both Hsp27 and Hic-5 activation resulted in their association within the same time frame as NE-induced contraction, and the inhibition of either p38 MAPK or Src inhibited the interaction between Hsp27 and Hic-5 and the contractile response
Su et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : TNF stimulation induced p38 MAPK dependent phosphorylation of MK2 and HSP27
Garcia et al., J Biol Chem 2009 : These data suggest that n-6 dietary fatty acids stimulate a set of interactions that regulates cell adhesion through RhoA and ROCK II via a p38 MAPK dependent association of HSP27 and p115RhoGEF
Zoubeidi et al., Cancer Res 2010 (MAP Kinase Signaling System...) : Because Hsp27 can be activated by both MAPK and Akt pathways, it is possible that interactions between IGF-I signaling and Hsp27 phosphoactivation function to promote castrate-resistant progression
Murai et al., Acta Med Okayama 2010 : We found that heatshock activated p38 MAPK at 3 min after exposure to a temperature of 44 degrees C in stress-hypersensitive PC12m3 mutant cells, while it activated JNK at 20 min after the same heat treatment
Jonak et al., J Dermatol Sci 2011 (MAP Kinase Signaling System) : Inhibition of p38-MAPK resulted in a downregulation of hsp27 in KC and SE. Additionally, in the presence of SB203580 Ca ( 2+ ) induced expression of pro-filaggrin and loricrin was inhibited at the protein level and expression of filaggrin, keratin 10, and transglutaminase 1 at the mRNA level
Clements et al., Am J Physiol Heart Circ Physiol 2011 : p38 MAPK dependent small HSP27 and aB-crystallin phosphorylation in regulation of myocardial function following cardioplegic arrest
Kato et al., Endocrinology 2011 : On the other hand, anisomycin, a p38 MAPK activator, caused the phosphorylation of HSP27 in both sphingosine 1-phosphate stimulated untransfected MC3T3-E1 cells and HSP27 transfected MC3T3-E1 cells
Shiryaev et al., Journal of molecular signaling 2011 : Both stress and cAMP elevating stimuli can cause F-actin remodeling, but whereas the in vivo role of p38MAPK-MK2 in stress triggered HSP27 phosphorylation and actin reorganization is well established, it is not known whether MK2 is involved in cAMP/PKA induced F-actin rearrangements
Nakashima et al., Cancer Lett 2011 (Pancreatic Neoplasms) : The inhibitions of p38 MAPK and MAPKAPK-2 reduced the phosphorylation of HSP27 and apoptosis in gemcitabine treated cells
Drastichova et al., PloS one 2012 (Morphine Dependence...) : Besides that morphine exposure up-regulated MAPK p38 ( isoform CRA_b ) which is a well-known up-stream mediator of phosphorylation and activation of HSP27 and a-B crystallin
Maizels et al., Endocrinology 1998 : FSH induced phosphorylation of HSP-27 was blocked by pretreatment with the p38 MAPK inhibitor SB 203580, indicating that p38 MAPK activation is necessary for FSH induced HSP-27 phosphorylation ... The results of these experiments show that the p38 MAPK pathway is activated in GC in response to FSH in a cAMP/PKA dependent manner, and that p38 MAPK activity is required for FSH induced HSP-27 phosphorylation as well as rounding/aggregation in GC