Gene interactions and pathways from curated databases and text-mining

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ICAM1 — NFKB1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kupatt et al., Circ Res 1999 (Myocardial Ischemia...) : We studied the role of early tumor necrosis factor-alpha (TNF-alpha) cleavage and nuclear factor-kappaB (NF-kappaB) activation on ICAM-1 expression and venular adhesion of PMN in isolated hearts after ischemia ( 15 minutes ) and reperfusion ( 30 to 480 minutes ) ... Decoy NF-kappaB but not control oligonucleotides blocked ICAM-1 upregulation and inhibited the subacute increase in PMN adhesion ... These data suggest that ischemia and reperfusion in isolated hearts cause liberation of TNF-alpha, activation of NF-kappaB , and upregulation of ICAM-1 , an adhesion molecule involved in inflammatory response after ischemia and reperfusion
Hsing et al., J Immunol 1999 : Surprisingly, up-regulation of Fas, CD23, and ICAM-1 was partially independent, and up-regulation of LFA-1 was completely independent , of CD40 induced NF-kappaB activation
Brand et al., Gastroenterology 1999 : Stimulation of ICAM expression is mediated by activation of the transcription factor NF-kappaB
Papi et al., J Biol Chem 1999 (Asthma...) : Rhinovirus induction of ICAM-1 promoter activity was critically dependent upon up-regulation of NF-kappaB proteins binding to the -187/-178 NF-kappaB binding site on the ICAM-1 promoter
Toyoshima et al., Biochem Biophys Res Commun 1999 (Carcinoma, Squamous Cell...) : These findings indicate that NO up-regulates ICAM-1 expression on cancer cells by a regulatory mechanism involving PKC and suggest that NF-kappaB , but not AP-1, might be involved in induction of ICAM-1 by NO in cancer cells
Kayal et al., Mol Microbiol 1999 : By infecting in vitro human umbilical vein endothelial cells ( HUVEC ) with L. monocytogenes, we found that wild-type bacteria induced the expression of the adhesion molecules ( ICAM-1 and E-selectin ), chemokine secretion ( IL-8 and monocyte chemotactic protein-1 ) and NF-kappa B nuclear translocation
Takizawa et al., Br J Cancer 1999 : Moreover, a NF-kappaB nuclear translocation inhibitor did not inhibit the induction of ICAM-1 expression by treatment with CDDP and 5-FU
Yan et al., Arterioscler Thromb Vasc Biol 1999 : Both iNOS and ICAM-1 are transcriptionally regulated by nuclear factor kappaB (NF-kappaB)
Ruetten et al., Mediators Inflamm 1999 : Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-kappaB but not protein tyrosine kinase : comparison to induction of iNOS ... Thus, the increase in the expression of ICAM-1 on J774.2 macrophages by endotoxin involves the activation of NFkappaB , but not of protein tyrosine kinase
Mori et al., Infect Immun 2000 (Stomach Neoplasms) : Activation of intercellular adhesion molecule 1 expression by Helicobacter pylori is regulated by NF-kappaB in gastric epithelial cancer cells ... These results show that H. pylori directly induces expression of ICAM-1 on gastric epithelial cells in an NF-kappaB dependent manner that may support leukocyte attachment during inflammation
Madge et al., J Biol Chem 2000 : Although Akt has been reported to activate NFkappaB, LY294002 does not prevent TNF- or IL-1 induced degradation of IkappaBalpha, beta, or epsilon, transcription of NFkappaB dependent E-selectin or ICAM-1 promoter-reporter genes, or surface expression of E-selectin or ICAM-1 in human EC
Takizawa et al., Clin Exp Immunol 2000 : These findings suggested that DEP induced up-regulation of ICAM-1 gene, and this process might be largely dependent on oxidant mediated NF-kappaB activation and p38-MAPK pathways
Amrani et al., Mol Pharmacol 2000 : Thapsigargin, an agent that depletes intracellular calcium stores, abrogated both cytokine mediated NF-kappaB dependent ICAM-1 mRNA transcription and protein expression but had no effect on IkappaB degradation
Zaninovic et al., Am J Physiol Gastrointest Liver Physiol 2000 (Pancreatitis) : Inhibitory analysis showed that activation of transcription factor nuclear factor-kappaB (NF-kappaB) was involved in ICAM-1 upregulation by cerulein, but NF-kappaB did not mediate basal expression of ICAM-1 mRNA in acinar cells
Chang et al., J Surg Res 2001 (Disease Models, Animal...) : Therapeutic effect of dimethyl sulfoxide on ICAM-1 gene expression and activation of NF-kappaB and AP-1 in septic rats ... We investigated the therapeutic effect of DMSO on intercellular adhesion molecule 1 ( ICAM-1 ) gene expression and activation of nuclear factor-kappaB (NF-kappaB) and activating protein-1 (AP-1) in a rat model of peritonitis sepsis ... The levels of ICAM-1 mRNA expression and activation of NF-kappaB and AP-1 in livers were determined at 3 and 6 h post-CI ... At 3 h post-CI surgery ( early sepsis ), DMSO treatment at 30 and 60 min post-CI surgery significantly inhibited sepsis induced ICAM-1 mRNA expression and activation of NF-kappaB and AP-1 ... DMSO has no effect on ICAM-1 gene expression and activation of NF-kappaB and AP-1 when administered at 90 min post-CI surgery
Kefer et al., Shock 2001 : Thus the oxidative modification of NF-kappaB secondary to the loss of ROS buffering capacity may regulate NF-kappaB binding to ICAM-1 promoter, and thereby ICAM-1 transcription in endothelial cells
Viita et al., Antioxid Redox Signal 1999 (Arteriosclerosis) : High expression of human 15-lipoxygenase induces NF-kappaB mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1 , and T-cell adhesion on human endothelial cells ... These cells were used to study the effects of 15-LO on the expression of vascular cell adhesion molecule 1 ( VCAM-1 ) and intercellular adhesion molecule 1 ( ICAM-1 ), activation of nuclear factor kappa B (NF-kappaB) , and T-cell adhesion on endothelial cells ... NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate ( PMA ) stimulation, as studied by flow cytometry
Uranishi et al., J Biol Chem 2001 : TLS augmented NF-kappaB dependent promoter activity of the intercellular adhesion molecule-1 gene and interferon-beta gene
Chen et al., Biochem Biophys Res Commun 2001 : In human vascular endothelial cells ( ECV304 cells ), troglitazone inhibited TNFalpha induced ICAM-1 gene expression by suppressing NF-kappaB/DNA binding activity, NF-kappaB transcriptional responses, c-Fos mRNA and protein levels via a ligand dependent, PPARgamma activated manner
Maaser et al., Clin Exp Immunol 2001 : Inhibition of endothelial NF-kappaB activation using the proteosome inhibitors MG-132 and BAY 11-7082 resulted in a significant decrease of ICAM-1 expression, indicating an important role for NF-kappaB in this response
Hideshima et al., Oncogene 2001 (MAP Kinase Signaling System...) : Importantly, the proteasome inhibitor PS-341 abrogated TNFalpha induced NF-kappaB activation, induction of ICAM-1 or VCAM-1, and increased adhesion of MM cells to BMSCs. Agents which act to inhibit TNFalpha may therefore abrogate the paracrine growth and survival advantage conferred by MM cell adhesion in the BM microenvironment
Voisard et al., BMC molecular biology 2001 : We hypothesized that tumor necrosis factor-alpha (TNF-alpha) induced and NF-kappaB mediated expression of intercellular adhesion molecule-1 ( ICAM-1 ) can be inhibited by antisense RelA p65 and NF-kappaB1 p50 oligonucleotides ( RelA p65 and NF-kappaB1 p50 )
Baron et al., Blood 2002 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Interestingly, inhibition of NF-kappaB activation by BAY11-67082 ( a specific NF-kappaB inhibitor ) resulted in down-regulation of ICAM-1 expression and a subsequent decrease in NK-induced killing of UT-7/9 transfectants
Viedt et al., J Am Soc Nephrol 2002 (Nephritis) : In contrast to IL-6 release, MCP-1 induced ICAM-1 expression was predominantly dependent on NF-kappaB activation
Ip et al., Clin Exp Allergy 2003 (Hypereosinophilic Syndrome) : In vitro studies of EoL-1 cells, an eosinophilic leukaemic cell line, confirmed that NF-kappaB plays an important role in the expression of ICAM-1 and recruitment of eosinophils in allergic inflammation
Wong et al., Am J Respir Cell Mol Biol 2003 : IL-3, IL-5, and GM-CSF could enhance p38 MAPK and NF-kappaB activity and induce ICAM-1 , CD11b, and CD18 expressions on eosinophils ... Therefore, the expression of ICAM-1 might involve both p38 MAPK and NF-kappaB activities, whereas the regulation of CD11b, CD18, and ICAM-3 expressions might be mediated through p38 MAPK but not NF-kappaB
Jewett et al., Hum Immunol 2003 : Thus, NFkappaB regulates inversely the expression of ICAM-1 and MHC class I antigens on HEp2 tumor cells and this may contribute to the resistance of these cells to NK cell mediated cytotoxicity
Tan et al., Sheng Li Xue Bao 2003 (Inflammation) : The effects of NF-kappaB inhibitor MG-132 on ICAM-1 expression were also observed ... It is suggested that a developing and intensive airway inflammation correlates closely with a persistent expression of ICAM-1 and repeated activation of NF-kappaB
Hierholzer et al., Arch Orthop Trauma Surg 2003 (Shock, Hemorrhagic) : Shock animals demonstrated increased mRNA levels of interleukin (IL)-6 and intercellular adhesion molecule (ICAM)-1 and increased activation of the transcription factors nuclear factor kappa B (NF-kappa B) and signal transducers and activators of transcription 3 ( Stat3 )
Cepinskas et al., J Cell Biol 2003 (Inflammation...) : Furthermore, cross linking of platelet-endothelial cell adhesion molecule-1 ( PECAM-1 ), but not intercellular adhesion molecule-1 , reduces human umbilical vein endothelial cell nuclear NFkappaB induced by interleukin 1beta
Li et al., J Immunol 2003 : In surviving cells, TRAIL activates NF-kappaB , induces expression of E-selectin, ICAM-1 , and IL-8, and promotes adhesion of leukocytes ... In surviving cells, TRAIL activates NF-kappaB , induces expression of E-selectin, ICAM-1 , and IL-8, and promotes adhesion of leukocytes
Ishibashi et al., Microb Pathog 2003 : Pretreatment of the BEAS-2B cells with the NF-kappa B inhibitors pyrrolidine dithiocarbamate ( PDTC ), MG-132, and SN50 resulted in a marked decrease in B. pertussis induced ICAM-1 expression, implying the involvement of NF-kappa B in ICAM-1 expression
Wang et al., J Immunol 2003 : Using various deletion constructs of ICAM-1 promoter, we show that ICAM-1 induction by IL-6 requires the activation of NF-kappaB
Zoog et al., Mol Immunol 2004 : Upon cellular entry, Antp-CD40 activated NF-kappaB dependent transcription, induced proteolytic processing of p100 to the p52/NF-kappaB2 subunit, and increased expression of CD80 and CD54 on the surface of B cells
Holden et al., Eur J Biochem 2004 : ICAM-1 expression is highly NF-kappaB dependent in A549 cells
Shibuya et al., Life Sci 2004 : BAY11-7082, an inhibitor of nuclear factor kappaB (NF-kappaB) activation, and MG132, a 26S proteasome inhibitor, reduced the TPA induced ICAM-1 expression but not the IFN-gamma induced one
Rahman et al., Am J Physiol Lung Cell Mol Physiol 2004 : This effect of cAMP was secondary to inhibition of NF-kappaB activity, the key regulator of thrombin induced ICAM-1 expression in endothelial cells ... Our data demonstrate that increased intracellular cAMP concentration in endothelial cells prevents thrombin induced ICAM-1 expression by inhibiting p38 MAPK activation, which in turn prevents phosphorylation of RelA/p65 and transcriptional activity of the bound NF-kappaB
Magnenat et al., J Mol Biol 2004 : We show that a TFZF that interacts directly with the ICAM-1 promoter at an overlapping NF-kappaB binding enhancer can overcome or synergistically cooperate with NF-kappaB induction of ICAM-1
Pazdrak et al., Gastroenterology 2004 : TNFalpha suppresses human colonic circular smooth muscle cell contractility by SP1- and NF-kappaB mediated induction of ICAM-1
Anwar et al., J Immunol 2004 : Blockade of thrombin induced ICAM-1 expression was secondary to inhibition of NF-kappaB activity, the key regulator of ICAM-1 expression in endothelial cells
Manna et al., J Biol Chem 2005 : IL-8 induces NF-kappaB dependent reporter gene expression as well as ICAM-1 , VCAM-1, and Cox-2 expression
Secchiero et al., Blood 2005 (Inflammation) : Unexpectedly, the antiadhesive activity of TRAIL was not due to interference with the nuclear factor kappaB (NF-kappaB) mediated up-regulation of surface intercellular adhesion molecule 1 ( ICAM-1 ), vascular cell adhesion molecule 1 ( VCAM-1 ), and E-selectin adhesion molecules in response to inflammatory cytokines
Buddenkotte et al., J Invest Dermatol 2005 (Dermatitis, Atopic) : Use of NF-kappaB inhibitors prevented upregulation of the cell adhesion molecule ICAM-1 in KTC indicating a direct role of NF-kappaB in PAR2 mediated upregulation of ICAM-1
Hagi-Pavli et al., Cell Physiol Biochem 2005 : ICAM-1 was up regulated by both peptides and this was attenuated by the adenylyl cyclase inhibitor SQ22,536 and the NF-kappaB inhibitor SN-50
Shi et al., Am J Physiol Gastrointest Liver Physiol 2005 : The overexpression of p65 NF-kappaB enhanced the constitutive expression of ICAM-1 , and TNF-alpha treatment had no further effect
Minhajuddin et al., J Immunol 2005 : Inhibition of mTOR by this approach promoted whereas over-expression of mTOR inhibited thrombin induced transcriptional activity of NF-kappaB , an essential regulator of ICAM-1 transcription
Miho et al., Cardiovasc Res 2005 : Although ICAM-1 expression is regulated by NF-kappaB , recent studies have suggested that additional signaling mechanisms may also be involved
Li et al., J Biomed Sci 2005 (Inflammation) : In conclusion, TVN efferent stimulation increases substance P release to trigger NF-kappaB mediated ICAM-1 expression and O ( 2 ) ( - ) and H ( 2 ) O ( 2 ) ROS production in the respiratory tract
Amin et al., Blood 2006 : Antisense oligodeoxynucleotides ( ODNs ) and inhibitors of Src, PI3K, p38, and NFkappaB significantly reduced rhMIF induced MN VCAM-1 and ICAM-1 expression ( P < .05 )
Mullan et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid...) : A-SAA induced expression of VCAM-1, ICAM-1 , and MMP-1 was down-regulated by NF-kappaB inhibition ... A-SAA induced expression of VCAM-1, ICAM-1 , and MMP-1 was down-regulated by NF-kappaB inhibition
Reed et al., Dig Dis Sci 2005 (Colitis...) : Colon tissue was collected for assessment of histological changes, NF-kappa B activation , myeloperoxidase (MPO) activity, and expression of NK-1R, SP, TNFalpha, IL-1beta, VCAM-1, ICAM-1 , E-selectin, CINC-1, MIP-1alpha, and iNOS
Bolick et al., Arterioscler Thromb Vasc Biol 2006 : Inhibition of rhoA and PKCalpha significantly reduced NF-kappaB activation, ICAM-1 induction , and monocyte adhesion to aorta ... Inhibition of rhoA and PKCalpha significantly reduced NF-kappaB activation, ICAM-1 induction , and monocyte adhesion to aorta
Hosokawa et al., Clin Exp Immunol 2006 : Both ICAM-1 and VCAM-1 expression by HGF was inhibited by nuclear factor-kappaB (NF-kappaB) activation inhibitor ( MG-132 )
Wang et al., Diabetes Metab Res Rev 2007 (Diabetes Mellitus, Experimental) : ADMA ( 30 microM ) significantly increased the activity of NF-kappaB and elevated the levels of ICAM-1 and TNF-alpha, and pre-treatment with rosiglitazone ( 10 or 30 microM ) markedly inhibited the increased activity of NF-kappaB and reduced the elevated levels of TNF-alpha and ICAM-1 induced by ADMA in cultured endothelial cells
Chen et al., Exp Eye Res 2006 (Translocation, Genetic) : GS inhibits the expression of the ICAM-1 gene in ARPE-19 cells stimulated with IL-1beta by blocking NF-kappaB subunit p65 translocation and by partially preventing IkappaB degradation
Ueno et al., Cardiovasc Toxicol 2006 (Atherosclerosis) : Inhibitors of p38 MAPK, PKC, and NF-kappaB suppressed nicotine stimulated expression of ICAM-1 and VCAM-1
Farley et al., J Invest Dermatol 2006 (Dermatitis...) : In HaCaT cells and in reconstructed human epidermis ( RHE ), FasL triggered a NF-kappaB dependent mRNA accumulation of inflammatory cytokines ( tumor necrosis factor-alpha, IL-6, and IL-1beta ), chemokines ( CCL2/MCP-1, CXCL1/GROalpha, CXCL3/GROgamma, and CXCL8/IL-8 ), and the adhesion molecule ICAM-1
Hernández-Vargas et al., Circ Res 2006 (Atherosclerosis) : Furthermore, the expression of monocyte chemoattractant protein-1 ( MCP-1 ), RANTES ( Regulated on Activated Normal T-cell Expressed and Secreted ), and intercellular adhesion molecule-1 ( ICAM-1 ) and the activation of nuclear factor-kappaB (NF-kappaB) were significantly reduced in aortic lesions from DKO mice
Hosokawa et al., Clin Exp Immunol 2006 (Periodontitis) : Phosphatidylinositol 3-kinase (PI3K) and nuclear factor-kappaB (NF-kappaB) inhibitor inhibit both ICAM-1 and VCAM-1 expression induced by TWEAK
Yi et al., Inflamm Res 2006 (Endotoxemia...) : Lung injury score, lung wet-to-dry weight ( W/D ) ratio, percentage of neutrophils ( PMNs ) in BALF, lung permeability index (LPI), intercellular adhesion molecule-1 ( ICAM-1 ) expression and activation of nuclear factor-kappa B (NF-kappaB) in the lungs were determined ... Lung injury score, lung wet-to-dry weight ( W/D ) ratio, percentage of neutrophils ( PMNs ) in BALF, lung permeability index (LPI), intercellular adhesion molecule-1 ( ICAM-1 ) expression and activation of nuclear factor-kappa B (NF-kappaB) in the lungs were determined
Traore et al., J Cell Biochem 2007 (Leukemia, Myeloid) : In addition, TPA induced ICAM-1 expression was blocked by inhibition of nuclear factor-kappaB (NF-kappaB) activation following pretreatment with BAY11-7085 ( a specific inhibitor of NF-kappaB activation )
Ohga et al., American journal of physiology. Renal physiology 2007 (Diabetes Mellitus, Experimental...) : High-glucose conditions increased the expression of ICAM-1 and the activation of NF-kappaB in cultured glomerular endothelial cells
Crispen et al., Prostate 2007 (Neoplasm Invasiveness...) : Treatment with alpha-tocopherol succinate ( VES ) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen independent PC-3, DU-145, and CA-HPV-10 cells ... Treatment with alpha-tocopherol succinate ( VES ) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen independent PC-3, DU-145, and CA-HPV-10 cells
Tao et al., J Surg Res 2007 (Crohn Disease) : The IL-1beta induced ICAM-1 was also inhibited by a potent inhibitor of NF-kappaB , MG132
Nizamutdinova et al., Int Immunopharmacol 2007 (Atherosclerosis) : The inhibitory effect of paeonol on ICAM-1 production might be mediated by inhibiting p38, ERK and NF-kappaB signaling pathways, which are involved in TNF-alpha induced ICAM-1 production
Lin et al., J Cell Physiol 2007 (Lung Neoplasms) : In previous study, interleukin-1beta (IL-1beta) has been shown to induce ICAM-1 expression through MAPKs and NF-kappaB in A549 cells
Newton et al., J Pharmacol Exp Ther 2007 (Pulmonary Disease, Chronic Obstructive) : In contrast, the corticosteroid, dexamethasone, was without effect on NF-kappaB dependent transcription or the expression of ICAM-1
Rajesh et al., Am J Physiol Heart Circ Physiol 2007 : HG markedly increased mitochondrial superoxide generation ( measured by flow cytometry using MitoSOX ), NF-kappaB activation , nitrotyrosine formation, upregulation of iNOS and adhesion molecules ICAM-1 and VCAM-1, transendothelial migration of monocytes, and monocyte-endothelial adhesion in HCAECs
Kang et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid...) : LIGHT mediated up-regulation of MMPs and intercellular adhesion molecule 1 was blocked by inhibitors of NF-kappaB and JNK, whereas up-regulation of vascular cell adhesion molecule 1 was blocked by inhibitors of phosphatidylinositol 3-kinase, as well as NF-kappaB
Nie et al., J Allergy Clin Immunol 2007 : ICAM-1 was induced in human and guinea pig parasympathetic nerves by TNF-alpha and IFN-gamma and was inhibited by dexamethasone and by an inhibitor of nuclear factor-kappaB (NF-kappaB)
Xu et al., World J Gastroenterol 2007 (Acute Disease...) : The beneficial effect of pioglitazone is multifactorial due to its anti-inflammatory activities, most likely through the inhibition of ICAM-1 expression and NF-kappaB activation
Tsou et al., Toxicol Appl Pharmacol 2007 : Inhibition of ERK, JNK, or NF-kappaB attenuates TNF-alpha induced ICAM-1 promoter activation and monocyte-endothelial monolayer binding
Bai et al., Biochem Biophys Res Commun 2007 (MAP Kinase Signaling System) : Rosiglitazone attenuates NF-kappaB dependent ICAM-1 and TNF-alpha production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation
Caposio et al., J Biol Chem 2007 : Support for this finding comes from the observation that IFI16 targeting with specific short hairpin RNA down-regulates NF-kappaB binding activity to its cognate DNA and inhibits ICAM-1 expression induced by IFN-gamma
El Mjiyad et al., J Virol 2007 : VZV also inhibits icam-1 stimulation of TNF-alpha by strongly reducing NF-kappaB nuclear translocation in MRC5 fibroblasts
Ishizuka et al., J Pharmacol Exp Ther 2008 : Inhibition of NF-kappaB activation and inhibition of ERK1/2 phosphorylation inhibited 20-HETE induced ICAM expression
Cepinskas et al., Am J Physiol Gastrointest Liver Physiol 2008 (Disease Models, Animal...) : Induction of CLP resulted in increased PMN accumulation, ICAM-1 expression, and activation of NF-kappaB in the liver of septic mice ... Induction of CLP resulted in increased PMN accumulation, ICAM-1 expression, and activation of NF-kappaB in the liver of septic mice ... In in vitro experiments, CORM-2 released CO attenuated LPS induced production of ROS and NO, activation of NF-kappaB , increase in ICAM-1 and iNOS protein expression and PMN adhesion to LPS stimulated HUVEC
Zerfaoui et al., Cell Signal 2008 : Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1 , expression in TNF stimulated smooth muscle cells : Differential requirement for PARP-1 expression and interaction
González-Ramos et al., Gynecol Obstet Invest 2008 (Disease Models, Animal...) : This study demonstrates, for the first time, that the NF-kappaB pathway is implicated in the development of endometriotic lesions in vivo and that NF-kappaB inhibition reduces ICAM-1 expression and cell proliferation, but increases apoptosis of endometriotic lesions, diminishing the initial development of endometriosis in an animal model
Terada et al., J Am Soc Nephrol 2008 (Fibrosis) : Furthermore, aldosterone augmented the promoter activity and protein expression of intercellular adhesion molecule-1 ( ICAM-1 ), which modulates the inflammatory response, and the profibrotic cytokine connective tissue growth factor (CTGF) in an SGK1- and NF-kappaB dependent manner
Yang et al., Nan Fang Yi Ke Da Xue Xue Bao 2008 (Colitis) : NF-kappa B activation is an important event in the development of DSS induced colitis in that activated NF-kappa B upregulates ICAM-1 expression during colonic inflammation
Rajan et al., J Cell Biochem 2008 : We further demonstrated that inhibition of NF-kappaB completely blocked TNF-alpha induced expression of ICAM-1 , VCAM-1 and E-selectin
Collins-Underwood et al., Free Radic Biol Med 2008 : We report that irradiating rat brain microvascular endothelial cells in vitro leads to increased ( i ) intracellular ROS generation, ( ii ) activation of the transcription factor NFkappaB , ( iii ) expression of ICAM-1 and PAI-1, and ( iv ) expression of Nox4, p22(phox), and p47(phox) ... Pharmacologic and genetic inhibition of NADPH oxidase blocked the radiation mediated upregulation of intracellular ROS, activation of NFkappaB , and upregulation of ICAM-1 and PAI-1
Chang et al., Invest Ophthalmol Vis Sci 2008 (Uveitis, Anterior) : GS suppresses EIU in rats by blockading the NF-kappaB dependent signaling pathway and the subsequent production of ICAM-1 and proinflammatory mediators
Lu et al., Cell Mol Neurobiol 2009 : In order to determine the possible effects of hemolysate on brain microvascular endothelial cells ( BMECs ), we examined the effects of hemolysate on the expression of intercellular adhesion molecule-1 ( ICAM-1 ) and monocyte chemoattractant protein-1 ( MCP-1 ), generation of reactive oxygen species ( ROS ), and NF-kappaB activation in rat BMECs
Yadav et al., Invest Ophthalmol Vis Sci 2009 (Cataract) : Cell growth was assessed by 3- ( 4,5-dimethylthiazol-2-yl ) -2,5-diphenyl tetrazolium bromide ( MTT ) assay and cell counting, the expression of alpha-SMA, beta-crystallin, and ICAM-1 by Western blot and immunocytochemical analysis, protein kinases by Western blot analysis, and NF-kappaB activation by gel shift and reporter assays
Shelton et al., J Biol Chem 2009 (Diabetes Complications...) : This up-regulation of Grx1 was concomitant with NFkappaB activation and induction of intercellular adhesion molecule-1 ( ICAM-1 )
Park et al., Anticancer Res 2009 (Fibrosarcoma) : As the induction of ICAM-1 requires activation of the transcription factor NF-kappaB , the effects of resveratrol on the activation of this factor in HT1080 cells was also investigated
Xue et al., Physiol Genomics 2009 : NF-kappaB regulates thrombin induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene ... Activation of NF-kappaB is essential for protease activated receptor-1 (PAR-1) mediated ICAM-1 expression in endothelial cells
Wu et al., American journal of physiology. Renal physiology 2009 (Nephritis) : However, the broad-spectrum caspase inhibitor Boc-d-fmk reduced NF-kB activation as assessed by gel shift assay, reduced phosphorylation of subunit IkappaBalpha, and significantly inhibited TNF induced expression of ICAM-1 and VCAM-1 as assessed by both real-time PCR and flow cytometry
Wang et al., Int Immunopharmacol 2009 : Nuclear factor-kappaB (NF-kappaB) could regulate transcription of VCAM-1 and ICAM-1 genes
Fazal et al., J Biol Chem 2009 : Here, we show a central role of cofilin-1, an actin binding protein that promotes actin depolymerization, in linking RhoA/ROCK pathway to dynamic alterations in actin cytoskeleton that are necessary for activation of NF-kappaB and thereby expression of ICAM-1 in these cells
Osterlund et al., Clin Exp Allergy 2009 (Asthma) : The release of cytokines and chemokines was regulated by NF-kappaB and MAPK activation in different ways, while expression of ICAM-1 was solely dependent on NF-kappaB activation
Zhang et al., Br J Pharmacol 2009 : These findings suggest that Ucn1 exerts pro-inflammatory effects by augmenting LPS induced expression of COX-2 and ICAM-1 in RAECs via CRF ( 2 ) receptors and the activation of p38MAPK and NF-kappaB
Katada et al., Inflammation 2010 (Inflammatory Bowel Diseases...) : The obtained results indicate that tissue levels of TNF-alpha, E-selectin and ICAM-1 protein expression, activation of NF-kappaB , and subsequent accumulation of PMN were elevated in I/R challenged jejunum
Benard et al., PloS one 2010 (Colitis) : Degraded carrageenan causing colitis in rats induces TNF secretion and ICAM-1 upregulation in monocytes through NF-kappaB activation
Azcutia et al., PloS one 2010 (Hyperglycemia...) : Both ERK 1/2 and NF-kappaB were necessary for VCAM-1 expression, but not for ICAM-1 expression
Yang et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : IL-1beta induced ICAM-1 expression, extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) phosphorylation, AP-1 activation, and nuclear factor-kappaB (NF-kappaB) p65 translocation were attenuated by the inhibitors of MEK1/2 ( U0126 ), JNK ( SP600125 ), AP-1 ( tanshinone IIA ), and NF-kappaB ( helenalin ) or transfection with respective short hairpin RNA plasmids ... These results suggest that in human RASFs, activation of ERK, JNK, AP-1, and NF-kappaB are essential for IL-1beta induced ICAM-1 expression and leukocyte adhesion
Ahmed et al., Molecular cancer 2010 (Breast Neoplasms) : Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kappaB dependent AP-1 mediated ICAM-1 expression in breast cancer cells ... The data revealed that OPN induces NF-kappaB activation and NF-kappaB dependent ICAM-1 expression
Song et al., J Pharmacol Sci 2010 (MAP Kinase Signaling System) : Overall, our results indicated that downregulation of ICAM-1 expression by ruscogenin in HUVECs might be mediated by nuclear factor-kappaB (NF-kappaB) , but not by mitogen activated protein kinase ( MAPK ) and Akt signaling pathways
Zhong et al., Biochem Biophys Res Commun 2012 (MAP Kinase Signaling System) : Omentin, NF-kB inhibitor ( BAY11-7082 ) and ERK inhibitor ( PD98059 ) reduced the up-regulation of ICAM-1 and VCAM-1 induced by TNF-a
Caldenhoven et al., Mol Endocrinol 1995 : Despite the importance of the DNA binding domain, we found that the transcriptional repression of NF-kappa B , mediated by GR, is not caused by binding of GR to the ICAM-1 NF-kappa B element, but by a physical interaction between the GR and RelA protein
Shin et al., J Biol Chem 1996 : These findings suggest that the induction of ICAM-1 and VCAM-1 expression requires NF-kappa B activation and that .NO attenuates IFN-gamma induced VCAM-1 expression primarily by inhibiting basal constitutive NF-kappa B activity in SMC
Franken et al., J Virol 1996 : Nevertheless, the simian EBV LMP1s retain most functions in common with EBV LMP1, including the ability to induce NF-(kappa)B activity in human cells, to bind the tumor necrosis factor associated factor 3 ( TRAF3 ) in vitro, and to induce expression of tumor necrosis factor-responsive genes, such as ICAM1 , in human B lymphocytes
Sakurada et al., Int Immunol 1996 (Arthritis, Rheumatoid) : The role of transcription factor NF-kappa B in the induction of cytokines and ICAM-1 upon stimulation with proinflammatory cytokines, IL-1 and tumor necrosis factor (TNF)-alpha was investigated in primary synovial fibroblasts obtained from patients with rheumatoid arthritis ( RA )
Kurose et al., J Clin Invest 1997 : CD18/ICAM-1 dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells
Kupatt et al., J Mol Cell Cardiol 1997 : Because upregulation of AP-1 through hypoxia alone did not affect ICAM-1 expression, we conclude that redox-sensitive NFkappaB activation triggers ICAM-1 upregulation
Wissink et al., Immunobiology 1997 : NF-kappa B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells
Chini et al., J Virol 1998 (Respiratory Syncytial Virus Infections) : Essential roles of NF-kappaB and C/EBP in the regulation of intercellular adhesion molecule-1 after respiratory syncytial virus infection of human respiratory epithelial cell cultures
Palmetshofer et al., Transplantation 1998 : BS-I strongly induced E-selectin, P-selectin, intercellular adhesion molecule-1 , and interleukin-8 mRNA in an NF-kappaB dependent manner
Hellerbrand et al., Hepatology 1998 (Liver Cirrhosis, Experimental) : Cytokines induce NFkappaB activity in activated but not in quiescent HSCs with subsequent expression of NFkappaB-responsive genes, such as intercellular adhesion molecule (ICAM)-1 and interleukin (IL)-6
Ishizuka et al., Clin Exp Immunol 1998 : These findings suggest that ICAM-1 or ELAM-1 expression of HUVEC stimulated via TXA2 receptors is augmented by induction of NF-kappaB and AP-1 binding activity through the PKC system, and that VCAM-1 expression is augmented by induction of NF-kappaB binding activity
Grammer et al., J Immunol 1998 (Burkitt Lymphoma) : By contrast, induction of apoptosis, activation of NF-kappaB , generation of granulocyte-macrophage CSF, and up-regulation of CD54 , MHC class II, and CD95 were unaffected by the TRAF3 dominant negative
Jobin et al., Gut 1998 : The role of NF-kappa B in ICAM-1 gene regulation was therefore examined by using different proteasome inhibitors in tumour necrosis factor alpha (TNF-alpha) stimulated IEC-6 rat intestinal epithelial cells ... Blocking TNF-alpha induced I kappa B alpha degradation with proteasome inhibitors reduced TNF-alpha induced NF-kappa B activation and ICAM-1 gene induction and notably decreased MOLT-4 cell adhesion without affecting Jun N-terminal kinase ( JNK/SAPK ) activity or de novo protein synthesis ... TNF-alpha induction of ICAM-1 expression is mediated by the transcription factor NF-kappa B and can be inhibited by blocking I kappa B alpha degradation
Kurokouchi et al., J Bone Miner Res 1998 (Bone Neoplasms...) : An antioxidant, N-acetyl-L-cysteine, significantly attenuated the TNF-alpha dependent increase in these mRNAs, and simultaneously reduced the activation of NF-kappaB by TNF-alpha, indicating that NF-kappaB mediates the TNF-alpha dependent expression of IL-6 and ICAM-1 in ROS17/2.8 cells
Oertli et al., J Immunol 1998 : Inhibition of NF-kappaB with the serine protease inhibitor N-tosyl-L-phenylalanine chloromethyl ketone blocked the HA-mediated expression of ICAM-1 and VCAM-1 in MCT cells
Lee et al., J Neuroimmunol 1998 : We determined that binding sites for both NF-kappaB ( -186 bp region ) and C/EBP ( -198 bp region ) are involved in TNF-alpha and IL-1beta mediated ICAM-1 upregulation