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ICOS — IL10
Text-mined interactions from Literome
Riley et al., J Immunol 2001
:
Second, on preactivated cells that had high levels of ICOS expression, CTLA-4 ligation blocked the
ICOS mediated induction of IL-4,
IL-10 , and IL-13, suggesting an interference with downstream signaling pathways
Wahl et al., J Am Soc Nephrol 2002
:
Interestingly,
interleukin-2 production by T cell hybridomas after antigen presentation by TEC was
enhanced by blocking antibodies to B7RP-1 and
ICOS
Witsch et al., Eur J Immunol 2002
:
ICOS and CD28 reversely
regulate IL-10 on re-activation of human effector T cells with mature dendritic cells ... Interaction of
ICOS with ICOS-L strongly
promoted IL-10 secretion, whereas the CD28/B7 pathway acted as a potent attenuator of IL-10 release ... Our data thus indicate a selective
regulation of
IL-10 secretion by
ICOS on re-activation of effector T cells with professional antigen presenting cells ( bearing CD80 and CD86 ) in lymphoid tissue
Feito et al., Eur J Immunol 2003
(MAP Kinase Signaling System) :
The association of phosphoinositide 3-kinase (PI-3K) to H4/ICOS was enhanced by
H4/ICOS cross linking, and PI-3K inhibitors
inhibited ERK and JNK activation and
IL-4/IL-10 secretion, but not p38 MAP kinase or ZAP-70 activation
Okamoto et al., J Rheumatol 2003
(Arthritis, Rheumatoid) :
H4/ICOS costimulation clearly
increased interferon-g, interleukin 4 (IL-4), and
IL-10 production by SF CD4+ T cells
Chen et al., World J Gastroenterol 2003
(Carcinoma...) :
ICOS-B7H interaction
induces the production of
IL-10 which inhibits the antitumor immune responses
Bellinghausen et al., Immunology 2004
(Hypersensitivity) :
In this system, costimulation of
ICOS strongly
enhanced the production of the T helper 2 cytokines interleukin (IL)-4, IL-5 and
IL-10 and, to a lesser extent, secretion of the T helper 1 cytokine, interferon-gamma ... Addition of exogenous IL-10 ( which is induced during VIT ) to the co-cultures before VIT also led to an inhibition of ICOS expression, while blocking of
IL-10 in co-cultures after VIT partially
restored the expression of
ICOS
Vermeiren et al., J Immunol 2004
:
Suppression was not mediated by
IL-10 and did not
require ICOS-ICOS ligand interaction, but depended on cell-cell contact
Ebert et al., Eur J Immunol 2004
:
The ability to produce
IL-10 could be maintained as a stable phenotype, but its secretion was strictly
dependent on
inducible costimulator (ICOS) signaling
Janke et al., Immunology 2006
:
In cocultures with moDC, the CD28 pathway was dominant over ICOS under all circumstances, except for the
ICOS mediated release of
IL-10
Mesturini et al., Eur J Immunol 2006
:
ICOS strikingly
potentiated secretion of IL-2, IFN-gamma,
IL-10 , and TNF-alpha, but not IL-4, promoted by optimal stimulation of CD3+CD28, and it was the key switching-factor of activation when cells received suboptimal stimulation of CD3+CD28 or stimulation of CD3 alone in the presence of exogenous IL-2
Tuettenberg et al., J Immunol 2009
(Common Variable Immunodeficiency) :
ICOS , an activation induced member of the CD28 family on T cells, is
involved in the induction of
IL-10 , which itself could contribute to induction of anergy and development of suppressive T cells ... Furthermore,
ICOS/ICOS ligand interaction
stabilizes IL-10R expression on T cells and thus renders them sensitive to IL-10 effects
Kim et al., J Immunol 2009
:
CD28 mediated costimulation dramatically enhanced T cell IL-10 production, yet neither
ICOS nor CD86 was
involved in
IL-10 production
Schaefer et al., J Leukoc Biol 2010
(Inflammation) :
Culture of cIELs from IL-10 ( -/- ) mice with IL-23 resulted in an increase in ICOS and IL-17 expression, whereas
IL-10 suppressed expression of
ICOS and IL-17
Nagamatsu et al., Immunol Cell Biol 2011
:
ICOS ligation
enhanced T-cell secretion of interferon-gamma ( IFN-? ) and
interleukin-10 (IL-10) , but not IL-2
Redpath et al., Eur J Immunol 2013
(Helminthiasis) :
ICOS controls Foxp3 ( + ) regulatory T-cell expansion, maintenance and
IL-10 production during helminth infection ... Moreover, during H. polygyrus infection,
ICOS deficiency
resulted in increased Foxp3 Treg-cell apoptosis, a Foxp3 Treg-cell specific impairment in
IL-10 production, and a failure to mount putatively adaptive Helios Foxp3 Treg-cell responses within the intestinal lamina propria