Gene interactions and pathways from curated databases and text-mining

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ICOS — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Parry et al., J Immunol 2003 : ICOS costimulation led to greatly augmented levels of PI3K activity compared with CD28 costimulation, whereas only CD28 costimulation activated c-jun N-terminal kinase
Nurieva et al., J Immunol 2007 : We found that CD28 and ICOS regulate sustained PI3K activity in primary T cells, which is required for NFATc1 up-regulation