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IFI44 — IL1B
Text-mined interactions from Literome
Jiang et al., Hypertension 2000
(MAP Kinase Signaling System) :
Interleukin-1beta activated
p44/42 MAPK, and this activation was enhanced in the presence of N-acetyl-L-cysteine
Saijonmaa et al., J Vasc Res 2001
:
TNF-alpha and
IL-1beta activated
p44/42 and p38 mitogen activated protein kinases ( MAPKs ) in HUVECs ; this was inhibited by the specific inhibitors of these kinases, PD98059 and SB202190, respectively
Hirafuji et al., Br J Pharmacol 2002
:
IL-1beta increased the phosphorylation of
p44/42 MAPK, while it did not apparently increase the phosphorylation of p38 MAPK ... DHA significantly potentiated the
IL-1beta induced phosphorylation of
p44/42 MAPK, while it had no significant effect on the phosphorylation of p38 MAPK
Vela et al., Mol Cell Neurosci 2002
:
Regarding intracellular signaling,
IL-1beta activated the p38 mitogen activated protein kinase ( MAPK ) but not the p42/p44 MAPK and, when combined with growth factors, intensified p38 activation but
inhibited the growth-factor induced
p42/p44 activation
Yang et al., Life Sci 2002
:
Sphondin ( 50 microM ) did not affect the
IL-1beta induced activations of
p44/42 MAPK, p38 MAPK, and JNK
Bamba et al., Am J Physiol Gastrointest Liver Physiol 2003
:
IL-1beta and TGF-beta1
induced an activation of ERK
p42/44 and p38 MAP kinases, and the MAP kinase inhibitors ( SB-202190, PD-98059, and U-0216 ) significantly reduced the IL-1beta- and TGF-beta1 induced IL-11 secretion
Lin et al., J Biomed Sci 2004
:
This hypothesis was further supported by the transient activation of
p42/p44 and p38 MAPKs
induced by
IL-1beta
Lee et al., World J Gastroenterol 2006
(MAP Kinase Signaling System) :
IL-1beta activates
p44/42 and p38 mitogen activated protein kinases via different pathways in cat esophageal smooth muscle cells ... Phosphokinase C ( PKC ) was found to play a mediating role in the
IL-1beta induced
p44/42 MAP kinase activity ... Based on these results,
IL-1beta induced
p44/42 MAP kinase activation is mediated by the Gi protein, tyrosine kinase, phospholipase C (PLC) and PKC
Kesherwani et al., Cytokine 2007
:
Quantitative
role of
p42/44 and p38 in the production and regulation of cytokines TNF-alpha,
IL-1beta and IL-12 by murine peritoneal macrophages in vitro by concanavalin A ... In the present study the quantitative
role of
p42/44 and p38 in the production of TNF-alpha,
IL-1beta and IL-12 by murine peritoneal macrophages, in vitro, on treatment with Concanavalin A ( ConA ) has been investigated ... The expression of TNF-alpha, IL-1beta and IL-12 was down regulated in the presence of PD98059 and SB202190 in a dose dependent manner, suggesting the involvement of
p42/44 and p38 in ConA
induced production of TNF-alpha,
IL-1beta and IL-12 by macrophages
Sodhi et al., Glycoconj J 2007
:
Pharmacological inhibitor of tyrosine kinase, PI3 kinase, protein kinase C,
p42/44 , p38, JNK and intracellular calcium immobilizing agent down
regulated the WGA induced expression of cytokines TNF-alpha,
IL-1beta , IL-12 and IFN-gamma
Sheng et al., J Neuroimmune Pharmacol 2009
(MAP Kinase Signaling System) :
IL-1beta triggered the activation of p38 and ERK1/2 (
p44/42) MAP kinase (MAPK) signaling pathways, but WIN55,212-2 mainly inhibited p38 MAPK phosphorylation