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IFNA1 — TLR7

Text-mined interactions from Literome

Urosevic et al., Clin Cancer Res 2004 (Carcinoma, Basal Cell...) : Via interaction with Toll-like receptor 7 on immune cells, imiquimod induces local production of cytokines, such as interferon ( IFN ) -alpha
Mandl et al., Nat Med 2008 (Acquired Immunodeficiency Syndrome...) : Here we show that sooty mangabeys have substantially reduced levels of innate immune system activation in vivo during acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells ( pDCs ) produce markedly less interferon-alpha in response to SIV and other Toll-like receptor 7 and 9 ligands ex vivo
Meier et al., Nat Med 2009 (HIV Infections) : pDCs derived from women produce markedly more interferon-alpha ( IFN-alpha ) in response to HIV-1 encoded Toll-like receptor 7 (TLR7) ligands than pDCs derived from men, resulting in stronger secondary activation of CD8 ( + ) T cells
Morimoto et al., Curr Drug Targets 2010 (Autoimmune Diseases...) : Recently, it has been uncovered that intracellular form of Opn ( i-Opn ) is a critical regulator for Toll like receptor-9 (TLR-9), TLR-7 dependent interferon-alpha ( IFN-alpha ) expression by plasmacytoid DCs and Th17 development
Bosinger et al., PLoS Pathog 2013 : In 2008 it was reported that plasmacytoid dendritic cells ( pDCs ) of SMs exhibit attenuated interferon-alpha ( IFN-a ) responses to TLR7/9 ligands in vitro, and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation