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IFNA5 — TYK2
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
IFNA5
→
TYK2
(indirect_complex)
You et al., Mol Cell Biol 1999, Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Myers et al., J Biol Chem 2001, Lamken et al., J Mol Biol 2004, Cajean-Feroldi et al., Biochemistry 2004, Roisman et al., J Mol Biol 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Xu et al., Frontiers in bioscience : a journal and virtual library 2008, Colamonici et al., Mol Cell Biol 1994, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Gauzzi et al., J Biol Chem 1996, Jiao et al., Mol Cell Biol 1996, Domanski et al., J Biol Chem 1997
-
Reactome Reaction:
IFNA5
→
TYK2
(reaction)
Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Lamken et al., J Mol Biol 2004, Cajean-Feroldi et al., Biochemistry 2004, Roisman et al., J Mol Biol 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Colamonici et al., Mol Cell Biol 1994, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Gauzzi et al., J Biol Chem 1996, Domanski et al., J Biol Chem 1997
Text-mined interactions from Literome
Platanias et al., J Biol Chem 1996
:
Binding of
interferon alpha ( IFN alpha ) to its receptor
induces activation of the
Tyk-2 and Jak-1 tyrosine kinases and tyrosine phosphorylation of multiple downstream signaling elements, including the Stat components of the interferon stimulated gene factor 3 ( ISGF-3 )
Novak et al., Growth Factors 1996
:
Instead of increased phosphorylation of JAK1 and JAK2 in response to G-CSF and interferon-gamma, and JAK1 and
Tyk2 in
response to
interferon-alpha/beta , we observed only an increase of phosphorylation of Tyk2 in response to all of these cytokines in NFS-60 cells
Krishnan et al., Eur J Biochem 1997
:
Kinase-deficient forms of Jak1 and
Tyk2 inhibit
interferon alpha signaling in a dominant manner
Gauzzi et al., Proc Natl Acad Sci U S A 1997
:
It was previously shown that
Tyk2 contributes to
interferon-alpha ( IFN-alpha ) signaling not only catalytically, but also as an essential intracellular component of the receptor complex, being required for high affinity binding of IFN-alpha
Yan et al., J Biol Chem 1998
:
This same fragment inhibits
interferon-alpha dependent tyrosine phosphorylation of
TYK2 , STAT1, and STAT2