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IFNB1 — IL12A

Text-mined interactions from Literome

Biron et al., Curr Opin Microbiol 1999 (Virus Diseases) : In particular, IFN-alpha/beta acts to inhibit interleukin-12 (IL-12) expression and IL-12 activation of innate natural killer ( NK ) cell IFN-alpha production, while inducing NK cell cytotoxicity and proliferation, and promoting adaptive T cell IFN-alpha responses
Cremer et al., J Immunol 2000 : The constitutive IFN-beta production also resulted in an increased production of IL-12 and IFN-gamma Th1-type cytokines and of the beta-chemokines macrophage-inflammatory protein-1alpha, macrophage-inflammatory protein-1beta, and RANTES
Wang et al., J Immunol 2000 (Multiple Sclerosis) : IFN-beta-1b inhibits IL-12 production in peripheral blood mononuclear cells in an IL-10 dependent mechanism : relevance to IFN-beta-1b therapeutic effects in multiple sclerosis
Van Weyenbergh et al., Immunol Lett 2001 : IFN-beta and TGF-beta differentially regulate IL-12 activity in human peripheral blood mononuclear cells
Yao et al., J Interferon Cytokine Res 2001 : We investigated whether the beneficial effects of IFN-beta in MS may involve its role in regulating nitric oxide ( NO ) and interleukin-12 (IL-12) in macrophages, as these immune modulators form part of the innate immune response to intracellular pathogens, such as C. pneumoniae ... In contrast to its effect on inducible NO synthase (iNOS), IFN-beta reduced induction of IL-12/p40 following culture with either elementary body antigens or rMOMP
Hussien et al., J Neuroimmunol 2001 (Multiple Sclerosis, Chronic Progressive...) : IFN-beta inhibits IL-12 production by DCs over unknown mechanisms ... IFN-beta also reduced IL-12 , but increased IL-10 production by DCs from both MS patients and healthy controls
van Seventer et al., J Neuroimmunol 2002 (Multiple Sclerosis) : Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells
Vollstedt et al., J Exp Med 2003 (Herpes Simplex...) : This resistance required interferon (IFN)-alpha/beta for viral and interleukin (IL)-12 for bacterial infections
Mattner et al., J Immunol 2004 (Disease Progression...) : IFN-beta treatment of BALB/c mice restored the NK cell cytotoxic activity, increased the lymphocyte proliferation, and augmented the production of IFN-gamma and IL-12 in the draining lymph node
Ito et al., Int Immunol 2005 : In the presence of exogenously added IFN-beta , IL-12 p40 and IL-12 p70 production was inhibited after LSO stimulation, but IL-12 p70 production was enhanced after PGN stimulation
Fahey et al., J Leukoc Biol 2006 : IFN-beta increases the expression of the anti-inflammatory cytokine IL-10 and suppresses IL-12
Carrieri et al., Immunopharmacol Immunotoxicol 2008 (Multiple Sclerosis, Relapsing-Remitting) : We examined the effects of interferon (IFN)beta-1a on interleukin (IL)-12p70 and IL-10 secretion in 27 Relapsing Remitting Multiple Sclerosis ( RRMS ) patients, divided in responders and non-responders
Ramgolam et al., Endocr Metab Immune Disord Drug Targets 2010 (Multiple Sclerosis, Relapsing-Remitting) : IFNbeta induces the production of the Th17-suppressive cytokines interleukin (IL)-27 and IL-12 in DCs and B-cells through the phosphorylation of signal transducers and activators of the transcription protein ( STAT ) 1
Zhang et al., Clin Neurol Neurosurg 2010 (Autoimmune Diseases...) : IFNbeta inhibited IL-1beta, IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and induced IL-27, IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Cousens et al., Proc Natl Acad Sci U S A 1997 (Cytomegalovirus Infections...) : Both IFN-alpha and IFN-beta inhibited fixed Staphylococcus aureus Cowan strain induction of IL-12 and IFN-gamma production by mouse splenic leukocytes in culture
Biron et al., Curr Opin Immunol 1997 (Virus Diseases) : IL-12 expression can be regulated by IFN-alpha/beta , and endogenous IFN-alpha/beta is responsible for the lack of IL-12 during viral infections that fail to elicit detectable production of this factor
Jiang et al., J Interferon Cytokine Res 1998 : Differential induction of IL-12 by IFN-beta and IFN-gamma in human macrophages ... In this study, we examined the effect of IFN-beta on IL-12 production in human macrophages, as IFN-beta is a natural protein produced by virus infected cells ... However, IFN-gamma can enhance IFN-beta induced IL-12 in these cells