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IFNG — PIK3R1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Nguyen et al., J Biol Chem 2001
:
IFN gamma activates
PI3K as well as Akt in a variety of cell lines
Sheu et al., Cell Signal 2005
(Inflammation) :
Both NO donor and
LPS/IFN-gamma markedly
activated the
PI3K activity and the phosphorylation of Akt and nuclear factor (NF)-kappaB DNA binding activity in mesangial cells, which could be inhibited by LY294002 and transfection of dominant negative vectors of PI3K/p85 and Akt
Hwang et al., Int J Hematol 2006
:
IFN-gamma did not
enhance SDF-1 induced activation of
PI3K/Akt or up-regulate the expression of CXCR4 or its function in bone marrow CD34+ cells
Harvey et al., Arterioscler Thromb Vasc Biol 2007
(Atherosclerosis) :
These studies provide novel insights into the
role of
PI3K/AKT and CK2 in
IFN-gamma signaling relevant to changes in macrophage gene expression during atherosclerosis
Boisvert et al., Mol Immunol 2007
:
Inhibition studies indicated that activation of ERK and JNK MAPKs and
PI3K/AKT are
necessary for both TCR- and TCR+alpha2 beta1 integrin dependent
IFN-gamma production and that Coll I increases TCR dependent activation of ERK and JNK MAPKs, and AKT
Peairs et al., Clin Exp Immunol 2009
(Lupus Nephritis) :
Mechanistically, AICAR inhibited the
LPS/IFN-gamma stimulated
PI3K/Akt signalling inflammatory cascade but did not affect LPS/IFN-gamma mediated inhibitory kappa B phosphorylation or nuclear factor (NF)-kappaB ( p65 ) nuclear translocation
Hardy et al., Immunology 2009
:
Taken together, our data indicate that PI3K and p38 MAPK modulate
IFN-gamma stimulated PKC-alpha nuclear translocation independently of JAK2 activity and that both
PI3K and PKC-alpha are
required for type IV CIITA and MHC II gene expression in IFN-gamma stimulated macrophages