Gene interactions and pathways from curated databases and text-mining

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IFNG — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Nguyen et al., J Biol Chem 2001 : IFN gamma activates PI3K as well as Akt in a variety of cell lines
Sheu et al., Cell Signal 2005 (Inflammation) : Both NO donor and LPS/IFN-gamma markedly activated the PI3K activity and the phosphorylation of Akt and nuclear factor (NF)-kappaB DNA binding activity in mesangial cells, which could be inhibited by LY294002 and transfection of dominant negative vectors of PI3K/p85 and Akt
Hwang et al., Int J Hematol 2006 : IFN-gamma did not enhance SDF-1 induced activation of PI3K/Akt or up-regulate the expression of CXCR4 or its function in bone marrow CD34+ cells
Harvey et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis) : These studies provide novel insights into the role of PI3K/AKT and CK2 in IFN-gamma signaling relevant to changes in macrophage gene expression during atherosclerosis
Boisvert et al., Mol Immunol 2007 : Inhibition studies indicated that activation of ERK and JNK MAPKs and PI3K/AKT are necessary for both TCR- and TCR+alpha2 beta1 integrin dependent IFN-gamma production and that Coll I increases TCR dependent activation of ERK and JNK MAPKs, and AKT
Peairs et al., Clin Exp Immunol 2009 (Lupus Nephritis) : Mechanistically, AICAR inhibited the LPS/IFN-gamma stimulated PI3K/Akt signalling inflammatory cascade but did not affect LPS/IFN-gamma mediated inhibitory kappa B phosphorylation or nuclear factor (NF)-kappaB ( p65 ) nuclear translocation
Hardy et al., Immunology 2009 : Taken together, our data indicate that PI3K and p38 MAPK modulate IFN-gamma stimulated PKC-alpha nuclear translocation independently of JAK2 activity and that both PI3K and PKC-alpha are required for type IV CIITA and MHC II gene expression in IFN-gamma stimulated macrophages