◀ Back to PTPN11

IFNG — PTPN11

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of PTPN11-STAT1 → IFNG (increases) Wu et al., J Biol Chem 2002
  Evidence: SHP-2 and Stat1 nuclear localization and their association in response to either epidermal growth factor or interferon-gamma (IFNgamma) were confirmed by immunofluorescent staining and affinity precipitation assays.
• NCI Pathway Database SHP2 signaling: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → SHP2 (PTPN11) (translocation, activates) Wu et al., J Biol Chem 2002
  Evidence: assay
• NCI Pathway Database IFN-gamma pathway: IFN-gamma (dimer) complex (IFNG) → SHP2 (PTPN11) (modification, collaborate) You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → SHP2 (PTPN11) (translocation, activates) Wu et al., J Biol Chem 2002
  Evidence: assay
• Reactome Reaction: IFNG → PTPN11 (reaction)

Text-mined interactions from Literome

Park et al., J Immunol 2005 : In the presence of IFN-gamma , TGF-beta1 rapidly induced in Th cells the synthesis of the PTP Shp-1, but did not induce Shp-2 or several members of the suppressor of cytokine signaling family of Jak-Stat inhibitors
Abschuetz et al., Cell Tissue Res 2006 (Glioma) : Moreover, stimulation with LPS and/or IFN-gamma resulted in a decreased expression of the viral replicative and cytotoxic protein NS1
Su et al., Biochem Biophys Res Commun 2007 (Urinary Bladder Neoplasms) : Therefore, the suppression of IFN-gamma signaling in HER-2/neu overexpressing bladder cancer cells might be due to SHP-2 upregulation